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literature surveys Monoterpenes are important constituents of many essential oils and are used extensively as flavouring agents in the food industry. Essay! Citral and linalool, both acyclic monoterpenes have been shown to cause peroxisome proliferation in essays the liver of mla format essay in a book rats (Jackson et al. ,1987; Roffey et al. , 1990). Peroxisome proliferators like clofibrate and essay many other hypolipidaemic agents when given to rodents result in an increase in the transcription of genes for proteins involved in peroxisome ?-oxidation of long-chain fatty acids and in the morphologically detectable proliferation of peroxisomes Reddy et al. Mla Format Cited Book! , 1983; Hawkins et al. , 1987). This phenomenon was also observed in rodents fed a diet rich in long-chain fatty acids but with a smaller response (Neat et al. , 1980). These agents have been shown simultaneously to enhance transcription of the gene for cytochrome P450IVA1 and increase the cellular content and activity of this enzyme (Gibson et al. Hana Essay! , 1982; Gibson, 1989). Based on these findings and studies conducted on a diverse number of mla format works cited essay book hypolipidaemic agents, a correlation was proposed between the ability of various agents to induce cytochrome P450IVA1 and cause peroxisome proliferation (Sharma et al. , 1988; Lake et al. , 1984). A number of mechanisms were proposed to explain this correlation. Sharma et al. (1988) proposed that the induction of cytochrome P450IVA1 by hypolipidaemic agents increases fatty acid w-hydroxylation and the formation of fatty dicarboxylic acids which cannot readily be metabolised by the mitochondria, therefore, the peroxisome is hana, presented with a substrate overload which adapts by cited in a proliferation in order to chain shorten these dicarboxylic acids for subsequent mitochondrial metabolism. Reddy et al. have proposed that peroxisome proliferators exert their effects by a ligand-receptor mediated mechanism (Reddy and Lalwani, 1983; Rao and Reddy , 1987; Reddy and Rao, 1986; Lalwani et al. , 1987) which causes both the essay elements, induction of peroxisome ?-oxidation and mla format essay in a transcription of the gene coding for the enzyme. Peroxisome proliferators are structurally diverse, therefore, a receptor theory could only be possible if: the receptor binds to a ligand conformation which is structurally common to different peroxisome proliferators, the receptor has different binding sites for different classes of peroxisome proliferators, there are different receptors for the classes of peroxisome proliferators but all leading to supernatural caesar, the same effect.

Recently, a mouse receptor (mPPAR, for mouse peroxisome proliferation activated receptor) has been isolated that is activated by mla format cited peroxisome proliferators (Issemann and Green, 1990; Dreyer et al. , 1992). Lock et al. (1989), link inhibition of the mitochondria into the correlation. Administration of DEHP results in a transient accumulation of small droplets of neutral lipid in the liver (Mann et al. , 1985; Mitchell et al. , 1985) which disappear when the peroxisomes are induced. The long-chain dicarboxylic acids (LCDCA) are also able to stimulate 3H-thymidine incorporation into DNA in isolated rat hepatocytes in culture (Lock et al. , 1989). In some cases, a correlation does not exist (Roffey et al. , 1990). Roffey et al. found that whilst citral induced peroxisome proliferation and cytochrome P450IVA1, linalool caused induction of peroxisome enzymes but not cytochrome P450IVA1.

Lazarow et al. (1982), observed that while bezafibrate does induce peroxisome ?-oxidation enzymes it does not elicit peroxisome proliferation in rat. Virtually all agents that induce proliferation of peroxisomes also induce hepatomegaly (Grasso and Hinton, 1991). Studies with fenofibrate (Price et al. , 1986), trichloroethylene (Elcombe et al. , 1985) and di-(2-ethylhexyl)phthalate (Mitchell et al. Synthesising! , 1985) have shown that peroxisome proliferators and liver growth correlate and mla format cited essay in a book are dose-dependent. The liver enlargement and increased enzyme activity regress on cessation of treatment (Elcombe et al. , 1985). There is synthesising, increasing evidence that prolonged treatment with peroxisome proliferating agents results in damage to hepatocytes and to an increase in cell turnover. Cells in cited in a book mitosis are particularly susceptible to hana montana, damage. It is thought that persistent tissue damage and cell regeneration may lead to tumour formation. Peroxisome proliferators, in addition also stimulate cytosolic hydrolase (Meijer and DePierre, 1987) in mice which may form diols from fatty acid epoxides due to the action of H 2 O 2 . They inhibit glutathione peroxidase and superoxide dismutase activity (Ciriolo. However, the peroxisomes of other animal organs and plant tissues lack this core, and so they are difficult to cited essay book, distinguish from the many other membrane-bound vesicles seen in electron micrographs unless histochemical staining (for example catalase) is used. One feature of peroxisomes is that they are inducible and, therefore, an administration of the hypolipidaemic drug clofibrate to rats leads to a tenfold increase in number of peroxisomes per liver cell. In certain yeasts grown on methanol, the peroxisomes can occupy almost the whole volume of the hana essay, cytoplasm.

Peroxisomes are involved in lipid degradation and mla format works essay in a book biosynthesis. A ?-oxidation pathway similar in function to case scribd, that of mitochondria is present in peroxisomes. Mla Format Works Cited Essay In A Book! However, the peroxisomal pathway differs from that of synthesising dmt mitochondria in several important respects: mitochondrial acyl-CoA oxidation is dependent upon the presence of carnitine, since the formation of acyl carnitine catalysed by mla format cited essay carnitine acyl transferase is an absolute requirement for the transport of the fatty acid moiety through the inner mitochondrial membrane. A carnitine dependent transport system for essay elements, acyl-CoAs does not exist in peroxisomes, it can catalyse the degradation of very-long-chain fatty acids (C 20 or greater), it does not act on short fatty acids (C 6 or less), the first enzyme in the pathway is an mla format works cited essay in a book, FAD-linked acyl CoA oxidase, rather than the FAD-linked dehydrogenase of the mitochondrial pathway, the first reaction is coupled to the formation of H 2 O 2 , the other enzymes are distinct gene products specific to the peroxisome. In the peroxisome ?-oxidation pathway, a fatty acid (usually C 8 - C 22 or more) is activated to an acyl-CoA derivative by an ATP-dependent acyl-CoA synthetase located in the peroxisome membrane. Elements Quiz! All subsequent reactions take place in in a the peroxisome matrix. The fatty acyl-CoA is reduced with the utilization of oxygen to trans-2-enoyl-CoA, yielding hydrogen peroxide; this reaction is catalysed by acyl-CoA oxidase, the rate limiting enzyme of peroxisomal ?-oxidation. The next two reactions are catalysed by caesar a bifunctional protein possessing the works essay, activities of enoyl-CoA hydratase and in julius essays 3-hydroxy acyl-CoA dehydrogenase. The final reaction of works essay in a book ?-oxidation is carried out by case hypertension scribd 3-ketoacyl-CoA thiolase which cleaves 3-ketoacyl-CoA into acetyl-CoA and a saturated acyl-CoA with two carbons less than the original molecule. The newly formed acyl-CoA then re-enters the ?-oxidation pathway. Each removal of two carbons results in the generation of one molecule of hydrogen peroxide.

The components of the mla format works book, peroxisomal ?-oxidation system differ significantly from enzymes of mitochondrial fatty acid ?-oxidation with respect to synthesising, their molecular and catalytic properties. For example, peroxisomal ?-oxidation does not require carnitine and mla format in a book is not inhibited by potassium cyanide. Isolated rat hepatic peroxisomes contain two carnitine acyltransferases in the organelle matrix (Markwell et al ., 1973, 1976, 1977; Moody and Reddy, 1974), carnitine acyltransferase and a transferase for supernatural caesar, medium-length chains such as octanyl carnitine. Their substrate specificity suggests that the C 2 and C 8 acyl-CoA products of hepatic peroxisomal ?-oxidation are converted to the corresponding carnitine derivatives and then passively diffuse out mla format, of the peroxisomes into the cytoplasm. Thus peroxisomal ?-oxidation may provide acetyl units for other cellular synthesis, or the acyl carnitine products may be further oxidised in the mitochondria.

The question to be addressed is, why is there the need for the carnitine acyltransferase, if the open prompts, fatty-acyl-CoA can passively diffuse into and out of the membrane? Mention has not been made of acylcarnitine translocase which functions as the mla format in a book, carrier for acylcarnitine. If it is obligatory that the fatty acyl-CoA be converted to acylcarnitine products, then a carrier behaving like a translocase should exist at supernatural in julius caesar essays, the membrane. Works Cited Book! Inhibiting either the acylcarnitine transferase or the translocase should inhibit fatty acid uptake by mitochondria, overload the peroxisome with substrates for its ?-oxidation pathway, inhibit either the acylcarnitine transferase at the peroxisome or the translocase which then cannot transport products out, therefore, there will be swelling of the peroxisome since the fatty acyl-CoA can easily diffuse into the matrix, and as a homeostatic mechanism result in elements peroxisome proliferation in order to compensate for the overload, leading to a futile cycle, since the products cannot be transported out, unless a mechanism comes into play to make the membrane more permeable, leading to mla format works essay book, diffusion of not only the dmt, products (fatty acids) but also H 2 O 2 . The cytochrome P450IVA1 is a member of the cytochrome P450IV isoenzyme. It is also called a fatty acid w-hydroxylase because it exhibits a high preference for hydroxylation of the terminal (w) methyl group over in a book, the thermodynamically favoured internal (w-n) methylene groups. Essay Explanation! The relative strengths of a methyl (-98Kcal/mol) and a methylene (-95Kcal/mol) C-H bond makes it thermodynamically more difficult to cited book, insert an synthesising, oxygen into the C-H bond of a terminal methyl group than the in a book, adjacent methylene group (Kerr , 1966). The oxidation of fatty acids by cytochrome P450 enzymes not specifically designed to carry out w-hydroxylations yields primarily w-1 and w-2 hydroxylated products (Tanaka et al. , 1990). The fatty acid w-hydroxylase represents approximately 1-2% of the cytochrome P450 in synthesising dmt uninduced rat liver microsomes and mla format essay in a book 16-30% after induction with clofibrate (CaJacob et al. , 1988). The preference for w-hydroxylation may be due to a limited substrate access to the ferryl oxygen at study hypertension, the active site. Some differences have been found between the members of the works cited book, P450IV family in dmt relation to substrate specificity and their tissue expression.

The liver P450IVA1 is active in the w-hydroxylation of lauric acid but does not metabolise prostaglandins, whereas the mla format works essay book, lung P450IVA1 catalyses the w-hydroxylation of several prostaglandins but not lauric acid (Tamburini et al. , 1984; Matsubara et al. , 1987). The liver P450IVA1 exhibits a narrow substrate specificity by metabolizing both lauric acid and arachidonic acid relatively well (Bains et al. Synthesising Dmt! , 1985) but not the prostaglandins (Matsubara et al. , 1987). Using the method of rationlization by molecular modelling of the substrates by Bains et al. it could be possible to see if the cyclic monoterpenes could be a substrate for P450IVA1, which I doubt. Some of the acyclic monoterpenes like citral are substrates because of their linear conformation which could be arranged in either trans (neral) or cis (citral) conformations. They can easily be superimposed unto the structure of lauric acid and arachidonic acid. The cyclic monoterpenes might possibly be substrates for the P450IVA4 since this enzyme prefers the cited essay, prostaglandins which have a central cyclopentane ring. If metabolism or some favourable reaction conditions does open the ring of the cyclic monoterpenes, then it could be possible for them to become substrates for the P450IVA1 (wishful thinking).

Twenty eight cyclic terpenes were studied using COMPACT computer graphic studies and none was found to ap literature open, be likely substrates for either P4501 or P450IIE (Lewis et al. , 1992). The cyclic monoterpenes are members of a class of compounds called the terpenoids which are biosynthesised by the acetate-mevalonate pathway. Theoretically the terpenoids are derived from the works in a, five-carbon isoprene unit (the running horse). The isoprene rule, states that all terpenoids are multiples of the isoprene unit (i.e. Essay Prompts! C 10 , C 15 , C 20 , etc.), although this is not strictly obeyed by natural products. Acetyl-CoA is the source of all the carbon atoms in Terpenes. ?-hydroxy-?-methylglutaryl-CoA is converted to mevalonate in a 2-stage reduction by NADPH catalysed by ?-hydroxy-?-methylglutaryl-CoA reductase. In the second stage, mevalonate is phosphorylated by ATP to form several active phosphorylated intermediates. By means of a decarboxylation, the active isoprenoid unit, isopentenylpyrophosphate is formed. The next stage is the condensation of a molecule of isopentenylpyrophosphate and 3,3-dimethylallylpyrophosphate to form Geranyl pyrophosphate. Earlier chemists hypothesized a direct participation of isoprene in the in-vivo synthesis of mla format works in a terpenes. This hypothesis was supported by the possible formation of dipentene from two isoprene units by a simple Diels-Alder process and by the wide occurrence, amongst essential oils, of caesar compounds with the dipentene structure.

Dipentene found this way is racemic. It is particularly abundant in turpentine oil. Its two optically active forms (+)limonene and (-)limonene are found respectively, in citrus fruit oil (oranges and lemons etc.) and peppermint oil. Other dipentene derivatives are widely distributed in nature. An objection to this early postulate, however, was that ISOPRENE itself did not appear to be present in nature and could only essay in a book be obtained by hypertension the pyrolysis of certain monoterpenes. The monoterpenes can occur in: acylic monocyclic bicyclic forms as hydrocarbons and as oxygenated derivatives such as; alcohols, aldehydes, phenols, ketones, oxides and esters. Possible pathways for the formation of the cyclic monoterpenes in the project.

An interesting stereochemical feature of many terpenes is the fact that both enantiomers (optically active isomers) exist in nature. In some cases, a plant species produces only one of the enantiomers, whereas, a different species may produce both. As with many other natural product compounds that exist in enantiomeric forms, such as alkaloids and amino acids, the works cited, physiologic responses elicited by each isomer can differ. For example, (+)carvone has an odour of caraway, whereas, (-)carvone produces a spearmint odour. These observations lend support to the stereochemical theory of olfaction which proposes that different kinds of synthesising dmt olfactory receptor sites are in the nose. In A Book! Odorant molecules could lodge on hana, these sites and would have shapes and sizes (varying in stereochemistry) that were complementary to the shape and size of the particular receptor. A proper fit at in a, the receptor would be required to initiate a nerve impulse that would register in the brain the hana montana, perception of the odour. Spearmint or ordinary garden mint consists of the dried leaf and mla format works essay flowering top of Mentha spicata . It has stalkless leaves and flower-clusters in elements quiz a slender spike. Mla Format Works Cited In A! Spearmint oil is ap literature, prepared steam distillation of Mentha spicata or of Mentha cardiaca and should not contain less than 55#37; of cited essay in a carvone.

Oil of spearmint contains from 45 to 60#37; (-)carvone, 6 to 20#37; of alcohols, and 4 to case hypertension, 20#37; of esters and terpenes, mainly (-)limonene and cineole. The optically isomeric form of carvone, (+)carvone is found in oil of caraway and oil of dill. Mla Format Cited Essay In A Book! Carvone when present in ap literature open ended essay prompts a plant appears to co-occur with limonene. Peppermint consists of the dried leaf and cited book flowering top of Mentha piperita . It has almost hairless leaves and oblong heads of flower-clusters. Peppermint oil is the volatile oil distilled with steam from the fresh overground parts of the flowering plant of Mentha piperita, rectified by distillation. Contains not less than 44#37; menthol. American peppermint oil contains from 50 to 78#37; of free (-)menthol and from 5 to 20#37; combined in dmt various esters such as the acetate. It also contains (+)menthone, (-)menthone, cineole, (+)isomenthone, (+)neomenthone, and (+)menthofuran. The biogenetic arrangement for the various species of mla format cited Mentha is as follows: Peppermint oil is a common flavouring ingredient used in chewing gums (Greenhalgh, 1979), toothpaste, confectionery and pharmaceutical products. A short-term oral toxicity study on male and female rats for 28 days demonstrated that peppermint oil causes brain lesions at doses of 40 and 100mg/kg bw/day which was confined to the white matter especially of the cerebellum (Thorup et al. , 1983a).

Since peppermint oil consists of all the compounds mentioned above, further studies were carried out to identify the culprit, and also find out if the synthesising dmt, oil or any of its components is mutagenic because of its extensive usage. Pulegone and menthol were inverstigated in rats (Thorup et al ., 1983b), by gavage for 28 days. Pulegone at 80 and 160mg/kg bw/day caused histopathological changes in liver and in mla format cited book the white matter of the cerebellum. No signs of encephalopathy was observed in rats given menthol. The toxicity of menthol was studied on four different in supernatural in julius caesar essays vitro systems (Bernson and Pettersson, 1983) covering organ, cellular and mla format works essay in a subcellular levels. 0.5mM menthol caused osmotic swelling and leakage of mitochondrial membrane on isolated rat liver mitochondria. Supernatural In Julius Caesar! It was suggested that menthol causes a deterioration of biological membranes. The acute oral LD 50 value was reported as 3300mg/kg ( Opdyke, 1976). In a different study, peppermint oil, menthol, menthone and pulegone were investigated in-vitro for their mutagenic potential in the Salmonella/mammalian-microsome test. Peppermint oil, menthol and works essay book pulegone were tested on salmonella tester strains TA 1537, TA98, TA1535 and TA100 at concentrations of 800, 160, 32 and 6.4µg per plate and did not demonstrate any mutagenic properties. Menthone on the other hand gave mutagenic responses with TA1537 (dose level 32 and essay elements quiz 6.4µg per plate without S9) and with TA97 (dose levels 800, 160, 32 and 6.4µg per plate without S9 and dose levels 160 and 32µg per plate with S9).

Thus it was concluded that menthone is mutagenic in the Ames Test (Anderson and Jensen, 1984). An in-vivo 28 days test on male and female rats was done with menthone at dose levels of mla format in a 200, 400 and argument 800mg/kg bw/day. Cyst-like spaces were seen histopathologically in the white matter of the cerebellum of the two highest dose groups ( Madsen et al ., 1986). The no-effect level for pulegone was 20mg/kg bw/day; menthol 200mg/kg bw/day and menthone lower than 200mg/kg bw/day. From an earlier study by mla format works cited in a Parke and Rahman , (1969) that terpenoids caused an induction of the drug metabolising enzymes, Madyastha et al ., (1985) tested the effects of pulegone on cytochrome P450 and found that pulegone when fed to quiz, rats at works, a dose of 400mg/kg once daily for 5 days destroyed cytochrome P450 and haem but the reaction was reversible since discontinuation of quiz treatment returned the enzyme levels to control levels within 4 days. This effect was restricted to pulegone alone since there was no significant loss in cytochrome P450 when the rats were pretreated with menthone or carvone. Since the three compounds are structurally similar, it was concluded that an exocyclic double bond allylic to a ketone as seen in pulegone may be the structural feature neede for the destruction of cytochrome P450. Ketone alone as seen in menthone or endocyclic double bond allylic to carbonyl function as in the case of cited essay in a carvone, do not cause haem linked destruction of cytochrome P450. The reduction in montana essay the level of liver microsomal cytochrome P450 and haem was accompanied by massive hepatotoxicity with an works cited essay, increased serum glutamate pyruvate transaminase and a decreased glucose-6-phosphatase ( Moorthy et al ., 1989).

A significant decrease in amino pyrine N-demethylase was also noticed after pulegone administration. Dmt! Pretreatment of cited essay book rats with phenobarbital potentiated the hepatotoxicity caused by pulegone, whereas, pretreatment with 3-methylcholanthrene protected from essay, it. It seems, P450IIB is converting pulegone to a reactive intermediate which then is responsible for these observed effects. Menthofuran (II) a metabolite of mla format works cited in a pulegone was found to be responsible for at least half of the hepatocellular necrosis caused by pulegone ( Thomassen et al ., 1988). Hana Montana Essay! Another study have indicated that another metabolite, unsaturated -ketoaldehyde (III) is the essay book, ultimate chemically reactive metabolite ( McClarahan et al ., 1989). When menthofuran (II) was incubated with rat liver microsomes in the presence of NADPH and O 2 , the ap literature ended prompts, -ketoaldehyde (III) was formed (Madyastha and Raj, 1990). The allylic alcohol readily undergoes intramolecular cyclization followed by dehydration to menthofuran.

It was proposed that the -ketoaldehyde (III) formed from in a, menthofuran (II) contributed to the toxicity mediated by pulegone in two ways: the -ketoaldehyde can covalently bind to the macromolecules resulting in toxicity. it acts as a precursor in the formation of a putative ultimate toxic metabolite p. cresol (VIII) (Madyastha and Raj, 1991. Limonene is a hydrocarbon monoterpene. Essay Quiz! It occurs in citrus fruits, mint, myristica, caraway, thyme, cardamon, coriander and many other oils. d-Limonene, a major component in many essential oils of citrus fruits is rapidly absorbed from the gastrointestinal tract and rapidly eliminated with no significant accumulation in the rat (Igimi et al ., 1974). It is converted in cited essay book man and in some other species of animals into two glycols, one of open essay prompts which is d-limonene 8,9-glycol as the major metabolite, and the other d-limonene 1,2-glycol as the minor one (Watabe et al ., 1981). d-Limonene exposure to air formed limonene oxide which caused skin sensitization in rabbits but not d-limonene (Karlberg et al ., 1991). Out of many terpenes, d-limonene was found to be one of the mla format, most effective agents to supernatural, solubilize cholesterol (Nishimura, 1972) and has been developed as a preparation to dissolve cholesterol gallstones by infusing into the gall bladder and / or the bile duct. The effects of d-limonene on lipids and drug metabolizing enzymes in works cited book Rat livers were studied (Ariyoshi et al ., 1975) and after a single oral dose of d-limonene (200-1200mg/kg) no effects were observed on hypertension, liver triglyceride, microsomal protein, cytochrome b 5 , and the drug metabolizing enzymes.

Glycogen content was slightly decreased at works, doses higher than 800mg/kg, and cytochrome P450 and essay d-aminolaevulinic acid synthetase activity was slightly increased at 1200mg/kg. After repeated treatment (400mg/kg/day) for 30 days, the mla format works essay, relative liver weight and hepatic phospholipid content were only slightly increased, and synthesising dmt liver and serum cholesterol were decreased 4 and 8#37; respectively of the phospholipid fatty acids, palmitic, linoleic and arachidonic acids were increased and stearic acid was decreased. Aminopyrine demethylase and works cited essay book aniline hydroxylase were increased 26 and 22#37; respectively, and cytochrome P450 and b 5 were likewise increased 31 and 30#37;. The d-ALA synthetase activity, the rate limiting enzyme in porphyrin biosynthesis was increased after single treatment with d-limonene at 1200mg/kg but not affected after repeated treatment for 30 days. Hana Montana Essay! This may partly be due to essay book, the rapid turn-over rate of d-ALA synthetase itself (Tschudy et al ., 1964; Bonkowsky et al ., 1973). d-Limonene was found to have chemopreventive and chemotherapeutic activity against chemically induced mammary ( Elegbede et al ., 1984; Maltman et al ., 1989), lung and stomach (Wattenberg and Coccia, 1991) cancer in case hypertension rodents.

When fed during the promotion/progression stage of mammary carcinogenesis, limonene inhibited the mla format essay book, development of open prompts tumours induced by works essay in a either 7,12 dimethylethylbenz(a) anthracene, which requires metabolic activation to its carcinogenic form or nitrosomethylurea, a directly acting carcinogen. Dietary limonene non competitively inhibits avian and rat liver HMG-CoA reductase activity and thereby reduces serum cholesterol levels and essay affects other aspects of mammalian isoprene metabolism as well ( Qureshi et al ., 1988). In mammals, mevalonic acid is metabolised to many isoprene species i.e.haem, cholesterol, tRNA's, ubiquinones etc. Cells treated with lovastatin (a potent inhibitor of HMG-CoA reductase) cease to grow and cited essay in a do not completely resume growth when cholesterol, ubiquinone or dolichol is added to the medium ( Goldstein and Brown, 1990; Maltese, 1990). Isoprenylation of proteins like low molecular weight, ras like GTP-binding proteins including p2 ras is required for cell growth and division.

Limonene significantly and selectively inhibits isoprenylation of ras-like small G-proteins while having no effect on the isoprenylation of several other proteins (Crowell et al ., 1991). Hypertension! The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to mla format works essay in a, growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of argument explanation cancer as well as heart disease. Mla Format Cited Essay Book! The bulk product of mevalonate metabolism, cholesterol is obtained from two sources; endogenously by synthesis from case study hypertension scribd, acetyl-CoA through mevalonate and exogenously from receptor-mediated uptake of mla format cited essay plasma LDL (low-density- lipoprotein). Mevalonate is also incorporated into non-sterol isoprenoids, as shown on the right.

Mevalonate homeostasis is montana essay, achieved through sterol-mediated feedback repression of the genes for HMG-CoA synthase, HMG-CoA reductase and the LDL receptor, as shown on the left and post-transcriptional regulation of works cited essay in a HMG-CoA reductase by one of the ap literature, nonsterol isoprenoids shown on the right. Cholesterol --- involved in membrane structure, Haem A and ubiquinone --- which partake in electron transport, Dolichol --- required for glycoprotein synthesis and. Isopentyladenine --- present in some transfer RNAs. Growth-regulating p21 ras proteins, encoded by mla format works ras protooncogenes and oncogenes, and nuclear envelop proteins are covalently attached to farnesyl residues, which anchor them to cell membranes. Inhibition of mevalonate synthesis prevents farnesylation of argument explanation these proteins and blocks cell growth. It is possible that the chemopreventive and chemotherapeutic action of d-limonene against mammary, lung and works cited essay stomach cancers may be due to its inhibition of the mevalonate pathway. There is no information as to if other terpenoids espercially the hydrocarbon monoterpenes similar in structure to limonene (even l-limonene) inhibit mevalonate synthesis in ap literature ended essay mammals. Cited In A! d-Limonene was found to essay, inhibit N-nitrosodiethylamine (NDEA) carcinogenesis of the forestomach and lung of female mice. d-Limonene and the citrus fruit oils can inhibit the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, NKK-induced carcinogenesis when administered 1 hour prior to carcinogen challenge ( Watterberg and Coccia, 1991). Although limonene can be consumed by rats (Elson et al ., 1988; Kodama et al ,. 1976) dogs (Webb et al ., 1990) and humans Kodama et al ., 1976) without toxicity, male rats alone exhibit nephrotoxicity (Webb et al ., 1989).

Limonene has been routinely consumed by humans without apparent adverse effects. Animal studies have indicated that this compound can be nephrotoxic under certain experimental conditions. Several studies have reported that the mature male rat treated with d-limonene and mla format in a book a wide variety of hydrocarbons, is the only species and sex to develop a unique form of study nephrotoxicity that is mla format works cited in a, characterized by the following specific triad of changes observed under the light microscope; an exacerbation of hyaline droplet accumulation, which is case study scribd, normally found within the cytoplasm of proximal convoluted tubule epithelial cells in mla format male rats, granular cast formation in essay the outer zone of the renal medulla and mla format cited essay in a book multiple cortical changes collectively classified as chronic nephrosis. In order to assess if this type of explanation nephrotoxicity occurs in a non-rodent species, the dog was used as a model (Webb et al ., 1990), but was found to be refractory to works book, the hyaline droplet nephropathy observed in male rats. Since this type of d-limonene nephrotoxicity is specific to the male rat, it may be inappropriate for interspecies extrapolation and human risk assessment. The cause of this toxicity was attributed to the reversible binding of d-limonene-1,2-oxide, a metabolite of d-limonene to alpha 2µ -globulin (Lehman-McKeman et al ., 1989; Dietrich and Swenberg, 1991) a naturally occurring low molecular weight urinary protein that is found in abundance only in adult male rats (Swenberg et al ., 1989). The complex formed is more resistant to lysosomal degradation than alpha 2µ -globulin alone. The reduced degradation of montana alpha 2µ -globulin-limonene complex leads to an accumulation of this complex in cited in a book the proximal convoluted tubule leading to the morphological changes characteristic of alpha 2µ -globulin nephropathy. Because alpha 2µ is a low molecular weight protein it is supernatural caesar essays, readily filtered at the glomerulus. Approximately 50#37; of alpha 2µ is absorbed in the proximal tubule and the remainder is excreted in the urine ( Neuhaus et al ., 1981). The proteins undergo endocytosis and are concentrated into vesicles called phagosomes which fuse with lysosomes.

Proteases in the phagolysosomes cleave the proteins at various sites forming amino acids and peptides which are returned back to the circulation. The function of the alpha 2µ is mainly as a carrier of lipophilic molecules. The mechanism of protein droplet accumulation is that the works essay in a, protein forms a complex with either d-limonene or its metabolite, making the protein more resistant to hydrolysis. These form crystalloid protein droplets which is associated with cytotoxicity. The injured cell is released from the basement membrane and in julius caesar sloughs into the lumen where it collects in granular casts in the thin loop of Henle or is cited, excreted in the urine. Synthesising! As a consequence of cell death, there is regeneration of neighbouring cells. Works Cited In A Book! The increased cell proliferation enhances the likelihood of an increase in spontaneous mutational events and also encourages clonal expansion of initiated cells.

The development of alpha 2µ -nephropathy is dependent on ap literature open essay prompts, the presence of alpha 2µ , since strains of rats, like the NBR (NCl-Black-Reiter) rat which are deficient in alpha 2µ -globulin, female rats and other species that do not synthesize this protein do not develop this disease ( Borghoff, 1990; Dietrich and Swenberg, 1991). Is it possible then that the olefinic bonds of other monoterpenes when metabolised to the epoxides may also bind to works in a, this transport protein?

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43 Resume Tips That Will Help You Get Hired. When you haven’t updated your resume in mla format a while, it can be hard to essay know where to start. Essay In A? What experiences and accomplishments should you include for the jobs you’ve got your eye on? What new resume rules and montana essay trends should you be following? And seriously, one page or two? Well, search no more: We’ve compiled all the resume advice you need into one place. Read on for tips and tricks that’ll make sure you craft a winning resume—and help you land a job. Mla Format Essay In A Book? Your resume should not have every work experience you’ve ever had listed on it. Think of your resume not as a comprehensive list of your career history, but as a marketing document selling you as the perfect person for the job. For each resume you send out, you’ll want to highlight only the argument essay explanation, accomplishments and skills that are most relevant to the job at hand (even if that means you don’t include all of your experience). Mla Format Cited Essay? Job search expert Lily Zhang explains more about what it means to montana tailor your resume here . 2. But Keep a Master List of All Jobs.

Since you’ll want to be swapping different information in and out depending on the job you’re applying to, keep a resume master list on your computer where you keep any information you’ve ever included on cited essay book, a resume: old positions, bullet points tailored for different applications, special projects that only sometimes make sense to include. Supernatural In Julius? Then, when you’re crafting each resume, it’s just a matter of cutting and pasting relevant information together. Essay In A? Think of this as your brag file . 3. Put the Best Stuff “Above the dmt, Fold” In marketing speak, “above the fold” refers to what you see on the front half of a folded newspaper (or, in the digital age, before you scroll down on a website), but basically it’s your first impression of a document. In resume speak, it means you should make sure your best experiences and accomplishments are visible on the top third of your resume. Mla Format Works Book? This top section is essay elements what the hiring manager is going to see first—and what will serve as a hook for mla format works cited essay book, someone to keep on synthesising dmt, reading. So focus on putting your best, most relevant experiences first—and then check out book, these five other marketing tricks to get your resume noticed . According to Zhang , the only occasion when an objective section makes sense is when you’re making a huge career change and need to explain from the get-go why your experience doesn’t match up with the position you’re applying to. In every other case? Consider whether a summary statement would be right for you —or just nix it altogether to save space and ap literature open essay focus on making the rest of your resume stellar.

There are lots of different ways to mla format cited essay book organize the information on your resume, but the good old reverse chronological (where your most recent experience is synthesising dmt listed first) is still your best bet. Unless it’s absolutely necessary in your situation, skip the mla format essay book, skills-based resume—hiring managers might wonder what you’re hiding. The two- (or more!) page resume is essay elements quiz a hotly debated topic , but the mla format essay, bottom line is this—you want the information here to supernatural caesar be concise, and making yourself keep it to works cited essay in a book one page is a good way to synthesising dmt force yourself to do this. If you truly have enough relevant and important experience, training, and mla format works cited essay book credentials to showcase on more than one page of your resume, then go for it. Hana Montana Essay? But if you can tell the same story in less space? Do. Mla Format Cited Essay In A Book? If you’re struggling, check out these tips for cutting your content down , or work with a designer to see how you can organize your resume to case study hypertension scribd fit more in less space. Can’t figure out how to tell your whole story on works essay book, one page, or want to be able to hypertension include some visual examples of your work? Instead of trying to have your resume cover everything, cover the most important details on that document, and in a book then include a link to your personal website , where you can dive more into what makes you the ideal candidate. We’ll talk about getting creative in order to montana essay stand out in a minute.

But the works, most basic principle of elements quiz, good resume formatting and mla format works book design? Keep it simple. Use a basic but modern font, like Helvetica, Arial, or Century Gothic. Essay? Make your resume easy on hiring managers’ eyes by using a font size between 10 and 12 and leaving a healthy amount of white space on mla format essay in a book, the page. You can use a different font or typeface for your name, your resume headers, and the companies for in julius caesar essays, which you’ve worked, but keep it simple and keep it consistent. Your main focus here should be on readability for mla format essay in a, the hiring manager. That being said, you should feel free to… Really want your resume stand out from the sea of Times New Roman?

Yes, creative resumes—like infographics, videos, or presentations—or resumes with icons or graphics can set you apart, but you should use them thoughtfully. If you’re applying through an ap literature open ended essay ATS, keep to the standard formatting without any bells and whistles so the computer can read it effectively. If you’re applying to a more traditional company, don’t get too crazy, but feel free to add some tasteful design elements or a little color to make it pop. No matter what, don’t do it unless you’re willing to put in the time, creativity, and design work to make it awesome. 10. Make Your Contact Info Prominent. You don’t need to include your address on your resume anymore (really!), but you do need to mla format in a make sure to include a phone number and professional email address (not your work address!) as well as other places the hiring manager can find you on the web, like your LinkedIn profile and Twitter handle. Synthesising Dmt? (Implicit in this is that you keep these social media profiles suitable for prospective employers.) You’ve heard before that hiring managers don’t spend a lot of time on each individual resume. So help them get as much information as possible, in as little time as possible. These 12 small formatting changes will make a huge difference. Mla Format In A? Know that design skills aren’t your strong suit but want your resume to study scribd look stunning? There’s no shame in getting help, so consider working with a professional resume designer.

This is arguably the most important document of works essay in a book, your job search, so it’s worth getting it exactly right! 13. Keep it Recent, Keep it Relevant. As a rule, you should only show the most recent 10-15 years of essay elements, your career history and mla format works cited only include the experience relevant to the positions to which you are applying. And remember to allocate real estate on your resume according to importance. If there’s a choice between including one more college internship or going into essay explanation more detail about your current role, always choose the latter (unless a previous job was more relevant to the one you’re applying to). Mla Format Cited Book? 14.

No Relevant Experience? No Worries! Don’t panic if you don’t have any experience that fits the bill. Instead, Zhang explains , focus your resume on your relevant and transferrable skills along with any related side or academic projects, and then make sure to pair it with a strong cover letter telling the hana essay, narrative of why you’re ideal for the job. Essay? No matter how long you’ve been in a job, or how much you’ve accomplished there, you shouldn’t have more than five or six bullets in synthesising a given section. In A Book? No matter how good your bullets are, the recruiter just isn’t going to get through them. Check out these tips for writing impressive bullet points . You may be tempted to ap literature open ended throw in cited tons of industry jargon so you sound like you know what you’re talking about, but ultimately you want your resume to essays be understandable to the average person. Remember that the first person who sees your resume might be a recruiter, an assistant, or even a high-level executive—and you want to works cited be sure that it is readable, relevant, and elements interesting to all of them. Use as many facts, figures, and numbers as you can in in a book your bullet points. How many people were impacted by your work?

By what percentage did you exceed your goals? By quantifying your accomplishments, you really allow the hiring manager to picture the level of work or responsibility you needed to achieve them. Argument Essay Explanation? Even if you don’t actually work with numbers, here are some secrets to adding more to your resume . People hire performers, so you want to show that you didn’t just do stuff, but that you got stuff done! As you look at your bullet points, think about how you can take each statement one step further and add in essay in a what the elements quiz, benefit was to your boss or your company. By doing this, you clearly communicate not only what you’re capable of, but also the direct benefit the employer will receive by hiring you. If you’re not sure how to explain your impact, check out mla format essay book, these tips for turning your duties into accomplishments . Describing soft skills on a resume often starts to sound like a list of meaningless buzzwords, fast. But being a “strong leader” or an “effective communicator” are important characteristics you want to get across. Think about how you can demonstrate these attributes in your bullet points without actually saying them. Zhang demonstrates here how you can show five different qualities with the same bullet point—try it yourself until you get the result you’re going for!

20. Study Hypertension? Don’t Neglect Non-Traditional Work. There’s no law that says you can only works essay in a put full-time or paid work on quiz, your resume. So, if you’ve participated in mla format book a major volunteer role, worked part-time, were hired as a temporary or contract worker , freelanced, or blogged? Absolutely list these things as their own “jobs” within your career chronology.

If every bullet in explanation your resume starts with “Responsible for,” readers will get bored very quickly. Use our handy list of better verbs to mix it up ! Use keywords in your resume: Scan the job description, see what words are used most often, and make sure you’ve included them in your bullet points. Not only is this a self-check that you’re targeting your resume to the job, it’ll make sure you get noticed in applicant tracking systems. Stuck on which words to include? Dump the job description into a tool like TagCrowd , which will analyze and spit out the most used keywords.

What words shouldn’t you include? Detail-oriented, team player, and hard worker—among other vague terms that recruiters say are chronically overused . We bet there’s a better way to describe how awesome you are. 24. Experience First, Education Second. Unless you’re a recent graduate, put your education after your experience. Chances are, your last couple of mla format in a book, jobs are more important and relevant to essay you getting the mla format works book, job than where you went to college. 25. Also Keep it Reverse Chronological. Usually, you should lay down your educational background by argument explanation, listing the most recent or advanced degree first, working in works cited reverse chronological order. But if older coursework is more specific to case the job, list that first to grab the reviewer’s attention.

Don’t list your graduation dates. The reviewer cares more about whether or not you have the degree than when you earned it. If you graduated from essay in a, college with high honors, absolutely make note of it. Synthesising Dmt? While you don’t need to list your GPA, don’t be afraid to showcase that summa cum laude status or the mla format works cited book, fact that you were in the honors college at your university. 28. Include Continuing or Online Education. Don’t be afraid to include continuing education, professional development coursework, or online courses in your education section, especially if it feels a little light. Kelli Orrela explains , “Online courses are a more-than-accepted norm nowadays, and your participation in them can actually show your determination and motivation to get the skills you need for your career.” Be sure to add a section that lists out all the hana, relevant skills you have for a position, including tech skills like HTML and Adobe Creative Suite and any industry-related certifications. Just make sure to skip including skills that everyone is expected to have, like using email or Microsoft Word.

Doing so will actually make you seem less technologically savvy. If you have lots of skills related to a position—say, foreign language, software, and leadership skills—try breaking out one of those sections and listing it on its own. Below your “Skills” section, add another section titled “Language Skills” or “Software Skills,” and detail your experience there. Mla Format Works Essay In A? Again—we’re going for skimmability here, folks! Feel free to include an hana “Interests” section on your resume, but only mla format works cited essay book add those that are relevant to the job. Are you a guitar player with your eye on a music company? Definitely include it. But including your scrapbooking hobby for a tech job at a healthcare company? Don’t even think about it.

32. Synthesising? Beware of Interests That Could Be Controversial. Works Essay In A? Maybe you help raise money for your church on the reg. Or perhaps you have a penchant for canvassing during political campaigns. Yes, these experiences show a good amount of supernatural in julius essays, work ethic—but they could also be discriminated against by someone who disagrees with the cause. Zhang explains here how to weigh the decision of cited book, whether to include them or not. Do include awards and accolades you’ve received, even if they’re company-specific awards.

Just state what you earned them for, e.g., “Earned Gold Award for having the elements, company’s top sales record four quarters in a row.” What about personal achievements—like running a marathon—that aren’t totally relevant but show you’re a driven, hard worker? Zhang shares the proper ways to include them. Gaps and mla format works essay in a book Other Sticky Resume Situations. If you stayed at a (non-temporary) job for only a matter of months, consider eliminating it from montana, your resume. According to The New York Times ’ career coach , leaving a particularly short-lived job or two off your work history shouldn’t hurt, as long as you’re honest about mla format works cited essay in a your experience if asked in ap literature open essay prompts an interview. If you have gaps of mla format cited book, a few months in your work history, don’t list the usual start and end dates for each position. Use years only (2010-2012), or just the number of years or months you worked at your earlier positions. If you’ve job-hopped frequently, include a reason for leaving next to each position, with a succinct explanation like “company closed,” “layoff due to downsizing,” or “relocated to new city.” By addressing the gaps, you’ll proactively illustrate the reason for your sporadic job movement and make it less of an issue. Re-entering the workforce after a long hiatus? This is the perfect opportunity for a summary statement at the top, outlining your best skills and accomplishments.

Then, get into your career chronology, without hesitating to include part-time or volunteer work. See more tips from Jenny Foss for killing it on your comeback resume. Don’t try to synthesising creatively fill in gaps on works, your resume. For example, if you took time out of the workforce to ended prompts raise kids, don’t list your parenting experience on your resume, a la “adeptly managed the growing pile of laundry” (we’ve seen it). While parenting is works cited essay in a book as demanding and intense a job as any out there, most corporate decision makers aren’t going to take this section of your resume seriously. 39. Ditch “References Available Upon Request” If a hiring manager is interested in you, he or she will ask you for references—and will assume that you have them.

There’s no need to supernatural caesar address the obvious (and doing so might even make you look a little presumptuous!). It should go without saying, but make sure your resume is free and clear of typos. And don’t rely on spell check and mla format cited grammar check alone—ask family or friends to open essay take a look at it for you (or get some tips from an mla format works cited essay in a editor on how to perfect your own work ). If emailing your resume, make sure to hana montana essay always send a PDF rather than a .doc. Mla Format Cited Essay? That way all of your careful formatting won’t accidentally get messed up when the hiring manager opens it on his or her computer. To make sure it won’t look wonky when you send it off, Google’s head of HR Laszlo Bock suggests, “Look at it in both Google Docs and Word, and essays then attach it to an email and mla format cited essay book open it as a preview.” Ready to save your resume and send it off? Save it as “Jane Smith Resume” instead of “Resume.” It’s one less step the hiring manager has to take. Carve out quiz, some time every quarter or so to pull up your resume and make some updates. Have you taken on new responsibilities? Learned new skills? Add them in.

When your resume is updated on a regular basis, you’re ready to pounce when opportunity presents itself. And, even if you’re not job searching, there are plenty of mla format works in a, good reasons to essay elements quiz keep this document in tip-top shape. Photo courtesy of Hero Images / Getty Images . Erin Greenawald is a freelance writer, editor, and mla format in a book content strategist who is passionate about elevating the standard of writing on case, the web. Erin previously helped build The Muse’s beloved daily publication and led the company’s branded content team. If you’re an cited in a individual or company looking for help making your content better—or you just want to elements go out to mla format works book tea—get in touch at argument essay, eringreenawald.com.

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Cyber Bullying Essays and Research Papers. ? Cyber bullying Monira Alosaimi Dhahran Ahliyya School A person may think a word or two . Works Cited Essay In A Book. that are typed up on the internet won’t affect anyone, she/he (they) might think there would be a billion comments and no one would pay attention to the one she/he (they) wrote; but guess what? People read these comments and hana montana they do get affected by it. With what the harsh comment that person wrote, she/he just cyber bullied someone. Although cyber bullying may not be taken. Abuse , Bullying , Cyber-bullying 904 Words | 5 Pages.

Bullying refers to any kind of aggressive behavior, which is normally intentional and entails am imbalance of strength or power. . Cyber bullying also referred to as social online cruelty can be described as an intentional aggressive act which is mla format works essay, carried out by an individual or group of montana essay, individuals against works essay book a victim done repeatedly over a long period of time and sent through electronic contacts. Argument Essay Explanation. Cyber bullying is cited, usually repeated over time unless it is a death threat. The definition of cyber bullying. Abuse , Aggression , Bullying 2159 Words | 5 Pages. major issues plaguing young men and essay explanation women of today.

They feel harassed, threatened and lonely because of mla format cited, this. In this paper I will outline what . cyber bullying is, what effects is has on essay prompts young adults and various technological tools that educators can use in the classroom to tackle this issue. Cyberbullying Cyber bullying is works cited essay in a, a worldwide social issue today. It is the hana essay, use of technology most likely social networks such as “Facebook, twitter and MySpace” to threaten. Abuse , Bullying , Cyber-bullying 1366 Words | 4 Pages. used in mla format essay in a book, cyber bullying . Cyber bullying is defined as the use of essay elements, internet, cell phones, or other . devices are used to send or post text or images intended to hurt or embarrass another person. Cyber bullying is a major problem affecting the younger generation these days. Cyber Bullying has many kinds of works essay, examples but a few would be the bullies continuing to email them when they don’t want them to, making sexual comments, and supernatural using hateful words online. Cell phones can be used in cyber bullying as well.

Abuse , Bullying , Cyber-bullying 1388 Words | 4 Pages. COINS 209-05 25 September 2012 Cyber Bullying Not everyone knows what cyber bullying is, so what . is it? Cyber bullying is when a child is mla format works cited, being harassed, threatened, or embarrassed by another child using the internet, cell phone or other digital device. Almost half of teens in essay elements quiz, the United States are cyber bullied. Females are more likely to participate in cyber bullying and get cyber bullied than a male will ( bullying statistics). Some children who are cyber bullied think the bullies do it. Abuse , Bullying , Cyber-bullying 1371 Words | 4 Pages. CYBER BULLYING Cyber bullying statistics refers to Internet bullying . . Mla Format Works Book. Cyber bullying is a form of teen violence that can do lasting harm to young people. Bullying statistics show that cyber bullying is synthesising, a serious problem among teens. By being more aware of cyber bullying , teens and adults can help to fight it Cyber bullying affects many adolescents and mla format cited essay in a book teens on a daily basis. Cyber bullying involves using technology, like cell phones and the Internet, to bully or harass another person.

Cyber bullying. Abuse , Bullying , Cyber-bullying 1005 Words | 3 Pages. Stephanie Baker Paper 3 English 112 11:00-11:50 Prof. S Callender Cyber Bullying Cyber . In Julius Caesar Essays. bullying is works cited essay, defined as persistent unwelcome behavior, mostly using unwarranted or invalid criticism, nit-picking, fault-finding, isolation and being singled out intentionally by others by the use of the internet, cell phones, or other technology. This may include spreading rumors about a particular person, or even pretending to synthesising dmt be someone else to trick them into revealing personal information on the internet. Abuse , Barack Obama , Bullying 1882 Words | 5 Pages. Running head: Bullying Issues 1 . Bullying Issues: Cyber bullying vs. Traditional Bulllying Horache Allen Compostion1 Jan 29, 2013 Bullying Issues 2 Bullying Issues: Cyber Bullying vs. Traditional Bullying Are you a victim of mla format works cited book, cyber bullying ? Or were you the. Abuse , Bullying , Cyber-bullying 1455 Words | 5 Pages. Social Networking and Cyber Bullying .? Kevin Roshanaie Eng.

240 Professor Sophie Sills March 8, 2012 So many students and . kids are victims of cyber bullying whether this bullying is in school or from home. I think parents need to supernatural have control over mla format works cited, who their kids talk to on face book and other social networking sites. Also I think school principals and administrators should take the necessary steps to prevent cyber bullying from school. Essay. Cyber bullying should be considered a crime and book I think. Abuse , Bullying , Cyber-bullying 1878 Words | 5 Pages. Cyber Bullying By Fernando Marinero Kasey Green What is Cyberbullying? ? Cyberbullying is the use of supernatural caesar essays, information technology . to repeatedly harm or harass other people in a deliberate manner. Works. Is It Wrong? ? While bullying is considered an essay quiz old notion, cyber bullying is fairly new to this day in mla format works cited essay, age. ? In an online survey conducted 52% of people said that yes cyber bullying was a serious problem, while the supernatural in julius caesar, other 48% said it was not. The Debate The people who agree that cyber bullying is a. Abuse , Bullying , Cyber-bullying 492 Words | 8 Pages.

The cyber -bullies have stepped out mla format, of the screen and into face-to-face contact. With this new kind of bully on the rise and ruthless, is she . the school’s responsibility? Schools should be held responsible for cyber bullying because the synthesising, crime extends from the computer to the school setting. Studies indicate that cyber - bullying incidents have quadrupled in past five years (Ross). Cyber - bullying has become a huge issue recently. Every time you turn on the news there is another bullying , or.

Abuse , Bullying , Cyber-bullying 1755 Words | 5 Pages. November 1 2011 Cyber Bullying and the Effects on mla format essay Lives Cyber - bullying may not seem like much, but . in reality there are real people behind these monitors with real feelings. Cyber -bulling has caused depression, and even driven some people to have low self-esteem, and insecurities that may sometimes cause them to supernatural in julius caesar harm themselves and others. Cyber - Bullying is a growing epidemic with children as well as teenagers that has to stop before someone ends up hurt or worse dead. “ Cyber bullying is defined. Abuse , Bullying , Cyber-bullying 1592 Words | 4 Pages. Cyber Bullying is worse than Physical Bullying Many people believe that bullying is just a phase . Works Cited In A. that everyone goes through in life. Before the internet, cell phones, and other modern day technology came around, bullying was just a comment made by someone in the hallway, a prank towards someone, or even a big punch in the face.

Now with Facebook, MySpace, emails, and cell phones, bullying has taken an even bigger toll and threat to people’s lives. Argument Explanation. Although cyber bullying is less physical than traditional. Abuse , Bullying , Cyber-bullying 1764 Words | 5 Pages. Cyber Bullying Introduction With today’s technology bullying has become easier then ever; the mla format essay in a book, children and youth . of argument, this generation do not even need to have personal confrontation. Cyber bullying can be defined as any communication posted or sent by a minor online, by instant messenger, e-mail, website, diary site, online profile, interactive game, handheld device, cell phone or other interactive device that is intended to frighten, embarrass, harass or otherwise target another minor.

Cyber bullying. Abuse , Bullying , Cyber-bullying 2330 Words | 6 Pages. technology, bullying is essay, evolving. Essay Explanation. Some people have started to mla format in a book call this change “ cyber bullying ,” which is defined . as “ bullying that involves the essay explanation, use of e-mail, instant messaging, text digital imaging messages and digital images sent via cellular phones, Web pages, Web logs (blogs), chat rooms or discussion groups, and other information communication technologies.” (Kowalski, Limber, Agatston 42) Through the use of online social networks, many teenagers are becoming victims of cyber bullying . Mla Format In A Book. As a result. Abuse , Bullying , Cyber-bullying 1694 Words | 5 Pages. PLAYED ON MEAGAN IS KNOWN AS CYBER BULLYING . IN THE YEARS SINCE I FIRST HEARD THIS STORY I’VE HEARD PLENTY MORE STORIES THAT FIT . THIS CATEGORY SUCH AS THE SUICIDE OF RYAN HALLIGAN, AND TYLER CLEMENTI JUST TO NAME A COUPLE. CONSTANTLY HEARING THESE STORIES IN THE NEWS LET ME KNOW THAT CYBER - BULLYING IS A GROWING PHENOMENON AFFECTING MANY LIVES AROUND THE WORLD WHICH IS WHY I CHOSE THIS TOPIC TO RESEARCH. TODAY I WANT TO TELL YOU WHAT PROFESSIONALS DESCRIBE AS CYBER - BULLYING ,SOME OF THE ACCREDITED RESEARCH. Abuse , Bullying , Cyber-bullying 1493 Words | 4 Pages.

Cyber Bullying : Technology will be the Death of Us Adam Koran English 112-05, Fall Semester Professor Stammler December . Essay Elements Quiz. 6, 2012 Adam Koran Koran 1 Courtney Stammler English 112-05 11/24/12 Cyber Bullying : Technology will be the works, Death of Us Everybody remembers not too long ago when the stereotypical “bully” was portrayed as a big scary boy who pestered other boys for their lunch money. Elements Quiz. Bullying is like a disease, and works in a book it has developed a strange mutation. This mutation allows. Abuse , Bullying , Cyber-bullying 2057 Words | 6 Pages. Addressing the Issue of Cyber Bullying2 Introduction Today, people all over the world have the capability to communicate with each other . Case Hypertension Scribd. with a simple click of a button. With these technological advancements, society’s teens are appealed to the uses of computers, mobile phones and works cited essay in a other electronic devices. Although many perceive social networking and technology as harmless amusement, the ones threatened by cyber bullying beg to differ. This recent craze of virtual harassment has inflicted agony. Abuse , Bullying , Cyber-bullying 1137 Words | 3 Pages. Cyber communication Cyber socializing or cyber communication has led this country to explanation a new age of . technology, but cyber communication is mla format works essay book, very dangerous because you can give out ap literature ended prompts, tons of mla format cited essay, information which can lead people to being cyber stalked for argument essay, one example.

Cyber communication definitely sounded like a good idea back in works book, the sixties when it was made for the army and only the case study, army to works essay book use (http://www.helium.com/items/1611017- cyber -communication-as-problem). Essay. Once it wandered in to the homes. Abuse , Adolescence , Cyber-bullying 1284 Words | 3 Pages. Cyberbullying Escalating In the article White House Conference Tackles Bullying by Miami Hall, she refers to mla format a quote by First lady Michelle . Obama, appearing with President Obama at the day-long White House Conference on hypertension Preventing Bullying . She says, “The issue is something we care about cited essay in a not only argument explanation as president and first lady but also as parents. It's tough enough being a kid today, and our children deserve the chance to learn and essay book grow without constantly being picked on, made fun of--or worse” (Hall). Abuse , Bullying , Cyber-bullying 1636 Words | 4 Pages. A 21st Century Epidemic: Cyber Bullying Madison Gordon-Lavaee Rhetoric 101 Professor Cole October 12, 2010 A 21st . Century Epidemic: Cyber Bullying The Internet has a lot to ap literature open ended offer: immediate answers, endless research, and easy communication with people all over the world. These were the intentions of the people who invented this product.

America focused on the invention of the Internet and works essay in a all its glory, but forgot to think about the evil that could come of it. It is generally known that. Abuse , Bullying , Cyber-bullying 2014 Words | 5 Pages. The Detrimental Effects of Cyber Bullying. Effects of Cyber Bullying The Detrimental Effects of Cyber . Bullying “Sticks and stones may break my bones but words will never hurt me.” This popular saying is echoed throughout playgrounds all over the United States.

If only open ended prompts every victim of bullying could adapt to this attitude. Bullying is a frequent experience for a large number of children and adolescents. In today’s society, victims of bullying are subject to traditional forms of mla format works cited in a book, bullying as well as. Abuse , Bullying , Cyber-bullying 2292 Words | 7 Pages. THE REALITY BEHIND THE CYBER WORLD: My thoughts on Cyber Bullying “ Bullying builds character like . nuclear waste creates superheroes. It’s a rare occurrence and often does much more damage than endowment”. (Van, 2011). Case Study Hypertension Scribd. Nowadays, our world is facing different problems, issues, and mla format works cited concerns that people hardly realize. Some of explanation, these issues are not properly addressed by cited essay book, our government for there are other issues that need to synthesising dmt be taken first of. One of these issues is cyber bullying . I know that all of. Abuse , Bullying , Cyber-bullying 2332 Words | 7 Pages. being bullying through the use of e-technologies.

For those of mla format cited essay in a, you who don't know what e-technologies are, here are some examples: cell . phones, text messages, multimedia messages, e-mail, and any web page accessed through the web such as myspace and or facebook. This problem that is synthesising, so common among children requires us all to come together, parents, children and their schools, to stop it. Since the motives of cyber bullies differ, the mla format cited in a, solutions and responses to each type of cyber bullying incident. Abuse , Bullying , Cyber-bullying 988 Words | 3 Pages. Cyber Bullying Cyber - bullying is open ended essay, when a person is essay in a, harassed, embarrassed, intimidated, terrorised, . tormented, threatened, or otherwise targeted by person using the Internet, interactive and essay elements quiz digital technologies or mobile phones by means of threats, sexual remarks, negative labels, ridicule, false statements or disclosure of works cited in a book, personal data. Essay Explanation. it is sometimes referred to as cyber -harassment or cyber stalking. The methods used are limited only by the child's imagination and mla format essay book access to technology.

Traditional. Abuse , Bullying , Cyber-bullying 948 Words | 3 Pages. Prosecuting Cyber Bullies Technology is synthesising, frequently being used to display personal information on social networking sites for everyone in the . Mla Format Works Cited Essay. world to see. With this instantaneous technology, the school bully has access to elements quiz an easier, more harmful, and anonymous way to intimidate their victim. Cyber bullying has become a form of harassment that is creating a myriad of problems for mla format book, teenagers and, therefore, needs to be dealt with properly. The sense of hypertension scribd, anonymity and the ability to disguise ones. Abuse , Bullying , Cyber-bullying 1192 Words | 4 Pages. Think Before You Type Jocelyn Barrera February 20 2015 Bullying has been a problem in schools since most of us . can remember, but as modern technology continues to advance bullying has taken on a new turning point. Children now dealing with a bully at school could escape it when he/she got home. Mla Format Cited In A Book. Unfortunately, that is no longer the case. New technologies make it possible for bullying to go beyond the quiz, classroom and into a child’s home life.

As technology evolves, so do. Abuse , Bullying , Cyber-bullying 1147 Words | 5 Pages. Persuasive Essay Outline: Cyber Bullying Posted on March 20, 2013 by mla format works, Roshan Promisel Here is hypertension scribd, a rough outline of my essay (some . Essay. body paragraphs will most likely be changed as I go): Introduction: Cyber bullying is a form of bullying that has been taking place a lot more in middle and high schools because of the improvement of technology and increased usage of social media networks. Something that has not really been established in these schools are punishments. Do you know if your middle school. Abuse , Bullying , College 1421 Words | 6 Pages. MJ Morin 11/29/12 Ms.

Clarke English 11 (CP) Cyber - bullying laws gone too far With the supernatural in julius, increasing use of social . Works Essay Book. networking, Cyber - bullying is at an all time high. One in four of the 14- to 24-year-olds who responded to the survey said they had experienced digital abuse within the past six months. Synthesising Dmt. About 20 percent said someone had written something mean or untrue about them online. (Cyberbullying crackdown) The question that needs to mla format in a book be asked is; is synthesising dmt, it ok for a child to works essay be jailed for a mentally. Abuse , Bullying , Cyber-bullying 1157 Words | 3 Pages. Cyber Bullying Affect in Hong Kong. 1 Assignment 2 Phenomenon of Cyber Bullying Among Teenagers in School *Group Members: -Higher Diploma in Information . Montana Essay. Technology (Web): Chiu Man Kai (EL) Wong Tsz Kin (Prince) Table of Contents: Introduction Page 3 Motivation of works cited essay in a, cyber bullying Page 4 The Characteristics and Effect of Cyber - Bullying Page 5 Handling of synthesising dmt, Cyber Bullying Page 6 Solution of Cyber Bullying Page 7 Conclusion Page 8 Reference Page 9 Appendix A - Cyber - bullying : issues and solutions for the school. Abuse , Bullying , Cyber-bullying 844 Words | 4 Pages.

The Link Between Cyber-Bullying and mla format essay Suicide. The Link Between Cyber Bullying and Suicide When people hear the elements, word “bully” they often think of the tough guy in school who . seems to mla format works essay in a push and shove his peers into montana essay lockers and take away their lunch money. The idea of this type of bully has become popular and many people today would consider it a means of toughening up and is also widely known as an inevitable part of growing up or a phase in mla format, a child’s life. Recently there has been a rise in dmt, a new form of mla format essay in a book, bullying ; cyber bullying . With the fast. Abuse , Bullying , Cyber-bullying 1985 Words | 5 Pages. The Danger of Teens and Social Media. pressure, Cyber - bullying , depression, and argument explanation the danger of sexual predators are only a few risks teens need to be aware of when . engaging in social media activities. With social media being at mla format essay book, an all time high in argument essay explanation, this day and age, most teens do not realize the mla format in a, significant effect it has on synthesising dmt their lives.

Indeed, it may be a great way to communicate with family and friends, however; more risk than benefits come along with the use of social media. Becoming one of the in a book, most common risk teens face today, cyber -bullying. A Great Way to argument explanation Care , Abuse , Adolescence 883 Words | 3 Pages. cyber bullying outline and thesis. patterns of online and offline behavior. There are consequences of law in offline stalking and mla format cited essay online stalking, and cyber -stalkers can be put . in jail.[10] Cyberstalking is argument essay explanation, a form of cyberbullying.[11] Comparison to Traditional Bullying Certain characteristics inherent in online technologies increase the likelihood that they will be exploited for deviant purposes.[12] Unlike physical bullying , electronic bullies can remain virtually anonymous using temporary email accounts, pseudonyms in chat rooms, instant.

Abuse , Bullying , Cyber-bullying 864 Words | 3 Pages. How Is Technology Affecting People Psychologically? person. Unfortunately, this negative online interaction is all too frequent. Works Cited Essay Book. Cyber bullying is the act of . Essay Prompts. bullying using electronic technology.

It has become so serious that laws have been passed to outlaw it; going as far as jail time. Cyber bullying occurs with one out of six children. It can be devastating because it can happen 24 hours per cited in a day and every day of the hana essay, week. The worst part about Cyber bullying is that it can even happen when the victim is alone. Cyberbullying Research Center. Cyber-bullying , Entertainment Software Rating Board , Nonviolent video game 994 Words | 3 Pages. Synthesis Essay Over Cyber Bullying. Introduction? : Whether students are the target, perpetrator, or observer, bullying appears to be a rite of passage . in schoolyards throughout the mla format works cited essay book, world. Although bullying is essays, discouraged by parents and works essay in a book school officials, it seems to be considered a normal part of growing up.

However, with the open ended essay prompts, introduction of the Internet and the rise of chat rooms, blogs, and social networking sites, cyber bullying has become an works essay in a book anonymous way to target and attack others. ADD Assignment? : Re. Abuse , Bullying , Cyber-bullying 1990 Words | 8 Pages. lives just because they cannot handle the stress and open ended essay prompts the judgement that people have made without thinking? As the book, Cyber Wellness . Representative of Class 3E6, I, Alexandra Udinov, although I cannot stop cyberbullying on my own, but I want to raise awareness on this issue and help prevent it. And by preventing it, I want to share to the people, which is argument explanation, all of you about cyber - bullying and what we can do to cited essay book put a stop to it. As inhabitants of the 21st century,we are,with no doubt bound to social. Anger , Cyber-bullying , Facebook 1258 Words | 4 Pages. create personal profiles to keep in contact with friends, to share photos also to share music.

MySpace and Facebook have earned millions of dollars however . negative publicity since their success has pinpointed the dangers of montana essay, sexual predators, cyber - bullying and works cited book even inappropriate content on their social networks. MySpace and Facebook have increased security measures but the dangers are still inevitable and the members know they enter at their own risk. In 1998, MySpace became an official website. 2008 , Cyber-bullying , Cyberstalking 2299 Words | 7 Pages. In recent discussions of popular media is essay explanation, dangerous to teens morality, a controversial issue has been whether cyber socializing has a negative . influence on today's teens. On one hand, some argue that cyber socializing has a positive influence on teens morality. According to this view's advocate, Far from works essay book, hampering adolescents skills or putting them in ap literature open prompts, harms way, cyber socializing helps teens build their own identity's and positively affect their morality. Mla Format Works In A. (Henry, n.p.) From this perspective. Cyber-bullying , Facebook , Morality 1522 Words | 4 Pages.

Why Do Cyber Bullying Laws Need to Be Enforced? Why do Cyber Bullying Laws Need to be Enforced? Several middle school students in western New York created a Facebook event . invitation Oct. 21, and they invited 60 of their friends to participate in a plan to torment the sixth-grader the next day. Hana Essay. As the result, 10 accepted the invitation and works cited in a some of the students posted offensive comments; one even proposed to kill the boy. When the mother of the proposed victim found out about that, she contacted to school officials. This is common news for many. Abuse , Bullying , Cyber-bullying 841 Words | 3 Pages. Bullying can be found in every school in the country. It is all too often part of the way young people interact in our society. Supernatural Caesar Essays. Every school . must recognize its extent and impact and take steps to stop it happening.

When bullying is in a book, ignored or downplayed, pupils will suffer ongoing torment and harassment. Most children who are bullied always commit suicide. Essay Explanation. Bullying can cause lifelong damage to in a book victims. (A school's failure to deal with bullying endangers the safety of all its pupils by allowing a. Abuse , Bullying , Cyber-bullying 1387 Words | 4 Pages. liberty they have with the internet. In the past three years, there have been many cases in synthesising dmt, the news where teens get together and bully and harass other . teens online, sometimes up until the point where they can’t handle the constant bullying anymore and essay in a book commit suicide. Cyber bullies use the essay, internet as their medium to say things they wouldn’t normally say in person, and mla format in a since it is more public, they know they are doing much more [public] harm to in julius essays the person. Take the works in a, Megan Meier case as an example; Megan. Cyber-bullying , Facebook , Internet 1559 Words | 4 Pages.

The Social Networking Effect on Teenagers. many features and hana essay become social outcasts because they form a social life on these websites. As a result, one-on-one interaction with friends, family and even . enemies are slowly phased out. To top all that off, social networking websites are haven for cyber bullies and stalkers and a playground for predators who are looking for their next target using fake profiles. Even after all these effects, critics still maintain that social networking websites are good for today’s youth because it helps them gain. Abuse , Cyber-bullying , Facebook 1631 Words | 4 Pages. not afforded this right. Mla Format Works Cited In A. It is doubtful that every piece of legislation enacted by our government can replace vigilant parents. Keen points out the . unfortunate case of a thirteen-year old girl, Megan Meier, who committed suicide, due to online bullying by a fabricated persona, whom turned out to scribd be her forty-seven year old neighbor, Lori Drew, the mother of girl with whom Megan had argued. Drew was not charged for works cited essay in a book, the murder because it wasn’t illegal (69). Drew should be held accountable and in julius essays penalized.

Abuse , Anonymity , Cyber-bullying 880 Words | 3 Pages. BULLYING Executive Summary Suicide is the third leading cause of death for adolescent children between grades 6-12 in mla format cited essay in a book, California, arguably . due in part to bullying , a form of supernatural essays, interpersonal violence that has emerged as an important public health issue in the United States (Burgess, 2006). Mla Format Works Cited. Since 1999, 43 states have passed laws requiring schools to supernatural in julius caesar essays adopt policies addressing bullying (Serabstein, 2007). However, the mla format essay book, inconsistency in application of anti- bullying policies across the country has led to. Abuse , Bullying , Cyber-bullying 1885 Words | 6 Pages. English 099 Cyber Bullying Bullies have been around for essay quiz, a long time, but in book, the past 10-to-15 years there is a new type of . Supernatural In Julius Essays. bullying that has developed called cyber bullying . Cyber bullying is similar to physical bullying ; however, the bullying takes place on the Internet and works cited essay book can happen at any time any day. The difference between cyber and physical bullying is that online the emotional and verbal abuse both exist; however, the essay elements, physical abuse is absent online.

Cyber bullying took a while before. Abuse , Bullying , Humiliation 1077 Words | 4 Pages. Cyber - Bullying in Todays World Cyber bullying is the mla format works essay in a book, cause of today’s problems, dealing with teens . Argument Essay Explanation. causing more harm than the intended harm to mla format works cited in a book peers. Essay Quiz. Cyber - bullying uses the Internet to harass, threaten, and cited essay in a harm others through social networking sites, like Facebook or MySpace. Cyber - bullying has many negative effects in the life of bullied students. Some of the essay explanation, effects are failure in academics, socially deprived of interactions with piers, and unfortunately, suicidal thoughts. Mla Format Works Cited Essay In A Book. Cyber - bullying . Abuse , Bullying , Education 811 Words | 3 Pages. The Impact Of Cyber Bullying On Young People’s Mental Health The overall aim of the project is to supernatural understand the impact of . cyber bullying on mla format cited essay book the mental health of young people aged 12-18. Essay Quiz. I wanted to explore: - The links between cyber and cited essay other forms of bullying - How aware parents are about cyber bullying - What schools do to monitor and deal with cyber bullying - Whether cyber bullying affects the way in montana, which young people use technology - Whether increasing use of technology, and new technologies. Abuse , Bullying , Psychological abuse 855 Words | 3 Pages.

?I watched a close friend of mine in mla format works essay in a, high school become the ended essay prompts, victim of cyber bullying . Mla Format Works Essay In A. She slowly started drifting from her . Explanation. friends, her family and other people close to mla format in a book her. She changed the way she looked at herself, other people, and the overall world. Synthesising Dmt. Depression is mla format works cited in a book, one of the largest known symptoms or effects of bullying in general. Some other effects could be the idea of hana montana, low self-esteem, along with self-worth. The idea of having no trust in other people, or the world is another common symptom. Abuse , Bullying , Meaning of works essay in a, life 2194 Words | 7 Pages. Prof. Ribeiro English 102-27 16 May 2012 Technology and Bullying Part I – What I Already Know About My Topic I don’t know much about ap literature open ended essay prompts . the topic I chose and I have never personally experienced bullying or cyber bullying myself. I have, however, seen on the news and read about cyber bullying and the growing trend it is becoming. Works Essay In A Book. I remember a very specific case that happened two years ago at Rutgers University where a closeted-gay college student’s roommate secretly videotaped him performing.

Abuse , Aggression , Bullying 2499 Words | 6 Pages. Soc. Research Paper May 22, 2013 Cyber Bullying Many people have heard of the term “ Cyber . Bullying ”. Some people may have even been involved in it, whether being bullied, bullying someone themselves, or just being a by-stander and watching it all play out before them. Case Hypertension. Others may have just heard of the extremely bad cases on the news or by word of mouth. No matter which way you look at it, this issue is mla format in a book, growing fast and starting to case study become out of control but with everyone’s help the problem can. Abuse , Aggression , Bullying 1280 Words | 4 Pages.

? Cyber Bullying What is Cyber Bullying ? Use of cell – phones, text messages, e-mail, instant . Cited In A Book. messages, web blogs, and postings to bully another student in any of the elements, ways described above. Examples of cyber bullying are sending threatening or insulting messages by phone and e-mail and spreading destructive rumors that ruin the reputation of works book, a fellow student or worker. Bullying can occur just about everywhere: in any kind of school- poor or wealthy public or private, single-sex or co-education. Abuse , Bullying , E-mail 1417 Words | 4 Pages. For decades, physical bullying has been a consistent problem for young people attending school. Ap Literature Ended Essay Prompts. Yet the rapid growth of the Internet has . redefined how students pick on one another. This is a sample essay written about the tragedies that have occurred as a result of cyber bullying in the last several years, as well as how school administrators, students, and parents can best go about protecting their loved ones from these attacks in mla format cited essay book, the future.

If you are interested in purchasing a custom essay on. Abuse , Aggression , Bullying 1677 Words | 5 Pages. From the school yard to elements quiz the tips of works, our youth’s fingers, bullying has always been a part of the typical school life and unfortunately over the . years it has only become worse. Essay Quiz. Due to the capabilities of today’s technology, items such as mobile phones, tablets and computers are the sole key to allowing us access to works social media. Technology provides significant benefits, particularly to the young people of essays, today however it needs to cited in a book be noted that it also has a dark side (Campbell, 2005). This rapidly. Abuse , Bullying , High school 1193 Words | 3 Pages. Cyber - bullying Cyber - bullying is the use of the Internet, cell phones, or other electronic . communication devices to spread harmful or embarrassing information about another person. Hana. With kids using electronic technology and communication tools such as social media, text messages, chats, and websites a new form of bullying begins. Works Essay In A. Some root causes of this social injustice would be the internet as it gives kids an online version of teasing that commonly exists in schools along with the potential. Abuse , Bullying , Catholic social teaching 2381 Words | 6 Pages.

Bullying and Facebook Twitter Google+ Complete Your Registration Now. RESEARCH DOCUMENTS BOOK NOTES AP NOTES StudyMode - Premium and Free Essays, Term Papers Book Notes . Cyber Bullying Essay Continues for 1 more page » Home » Computers Internet Cyber Bullying Essay By Merlin920 | April 2012 Zoom InZoom Out Page 1 of 2 Adam Grabenhorst Mrs. Dressler English 2 15 January 2012 Cyber Bullying Peer to case study hypertension peer bulling is cited in a, nothing new. It has been going on for generation after generation. However the times have now changed since. Abuse , Bullying , Cyber-bullying 583 Words | 4 Pages. Beituni Bnbnb Roeback Com 101 068 12-8-10 Social Networking Argumentative Essay Are social networking sites good for our society? Social . Montana. networking sites can be harmful because they can affect the lives of many for the worse by allowing cyber bullying and leading to short attention spans.

Some people believe that social networking sites expose children to mla format works cited essay predators, increase vulnerability to computer viruses, lower worker productivity, and hana montana promote narcissism and short attention spans. Others. Bullying , Cyber-bullying , Facebook 852 Words | 3 Pages. Bullying Is No Longer Just on the Playground. Mukherjee English 1113 March 27, 2013 Bullying has been around for mla format cited, centuries and essay explanation is found in all human . cultures across the world. Bullying is a natural behavior; it is part of the human condition. Mla Format Works Cited Book. No matter where you go there will always be groups or individuals that single out other groups or individuals. Bullying is used as a form of showing dominance or social status. Supernatural Caesar. Bullying consists of spreading rumors, attacking someone physically or verbally, making.

Abuse , Bullying , Cyber-bullying 1614 Words | 4 Pages. WRT-101-118 Professor Petillo Unit 4 First Draft 3 December 2014 Chased into Cyberspace People are cruel, this is nothing new. What is new is the decline . of the traditional form of book, bullying and the rise of cyber bullying . Jessica Bennett in her article The Flip Side to Internet Fame explains the effects of cyber bullying using great examples and details. Synthesising. Instead of being chased around the mla format works cited essay in a, playground young people have decided to take it to the Internet, where they can hide behind their screens and batter. Abuse , Bullying , English-language films 1559 Words | 6 Pages. are bullied, also known as cyber - bullying . Ap Literature Open Ended Essay Prompts. Anything said, written, or displayed on mla format cited in a the internet is permanently there once it . is posted. Case Study. It is possible to delete any posts off of an account but it does not mean it has been completely taken off the internet.

The same goes for text messages, even though text messages may be deleted on a cell phone, old text messages can still be brought up and mla format essay in a book printed out through the phone carrier. This has become a big issue with bullying because bullies feel that. Abuse , Bullying , Communication 1354 Words | 4 Pages. Case Study- Cyber Bullying 2 December 2010 It was 7:00 a.m., and Skylar rose out of his bed just like any other day. He got . dressed, combed his hair, brushed his teeth, grabbed a pop tart and was out the in julius essays, door. Mla Format Works Cited In A Book. Skylar is in the eighth grade and he has been bullied since fourth. Chris Jacobson has picked on elements him with his “gang” for the past four years.

They tease him about his braces, the way he wears his clothes, being too skinny, and mla format book anything they can think of. On top of that, Skylar has suffered. Abuse , Bullying , Catholic Church 1572 Words | 4 Pages.

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essays idleness Authors born between 1100 and book, 1300 CE. Click Up For A Summary Of Each Author. Yoshida Kenko (1283-1350 CE) in synthesising his early career as a Japanese court official also emerged as a celebrated poet. At age 41 he became a Zen Buddhist monk. Mla Format Works Cited. His subsequent Essays in Idleness shows the application of Zen to a philosophy of social life.

In Kenko’s writings we see the Buddhist ideals of synthesising, naturalness, humility, simplicity, and meditation worked out in relation to daily affairs. Kenko’s Essays , probably written about 1340 CE, contains 243 sections of works cited, various lengths, from short aphorisms to meditations covering several pages. A note of resignation that sometimes occurs in Kenko’s thought is probably due to the experiences of the turbulent period in which the writings were composed—rather in the way that Epictetus was influenced by the times in which he lived. Kenko ranged widely in his choice of subjects, touching on ardent love, social etiquette, house design, drunkenness, thought impressions, and the brief span of essay, life. Mla Format Cited In A. He urged his readers to make the most of their time on earth, but in this he stressed the argument essay virtues of contemplation and thought. In one remark he suggested that the pleasure of reading a book alone in the lamplight is beyond compare.

1 It is a joyful thing indeed to hold intimate converse with a man after one's own heart, chatting without reserve about things of interest or the fleeting topics of the world; but such, alas, are few and far between. Not that one desires a companion who will sit opposite and never utter a word in contradiction—one might as well be alone. Far better in hours of loneliness the mla format works cited essay in a company of one who, while he will listen with respect to supernatural caesar essays your views, will disagree a little, and argue, saying Yes, that is so, but . . . , or For this reason such and such is the case. And yet, with those who are not of the same way of thinking or are contentious, a man can discuss only things of passing interest, for the truth is there must not be any wide gulf between bosom friends. 2 Though the breeze blow not, the mla format works cited essay flower of the heart of man will change its hue. Now looking back on months and years of intimacy, to essay quiz feel that your friend, while you still remember the moving words you exchanged, is yet growing distant and living in a world apart—all this is sadder far than partings brought by cited essay death.

3 Although some will say, After all this time, why stand on ceremony?'' I myself feel that it is a sign of genuine and proper feeling when even the most inseparable friends treat one another, if the occasion demands, with due reserve and decorum. On the other hand, it is sometimes well for people who are not intimate to speak freely. 4 To while away the idle hours, seated the livelong day before the inkslab, by hypertension jotting down without order or purpose whatever trifling thoughts pass through my mind, truely this is a queer and crazy thing to do! 5 It is desirable to have a knowledge of true literature, of composition and versifying, of wind and string instruments; and it is well, moreover, to be learned in precedent and court ceremonies, so as to be a model for others. One should write not unskillfully in the running hand, be able to sing in a pleasing voice and keep good time to music; and, lastly, a man should not refuse a little wine when it is pressed upon mla format essay book him. 6 To sit alone in the lamplight with a book spread out before you, and hold intimate converse with men of unseen generations—such is a pleasure beyond compare. 7 However gifted and case scribd, accomplished a young man may be, if he has no fondness for women, one has a feeling of something lacking, as of a precious wine cup without a bottom. Admire the condition of a lover! Drenched with dews and frosts and aimlessly wandering; ever concerned to shun the world's reproof and mla format works essay book, escape his parents' reproaches; hither and thither pursued by doubt and distress; and spending his nights withal sleepless upon dmt a solitary couch.

But it is well that a man do not become addicted to lewdness, a constant and familiar companion of women. Of all things that lead astray the heart of man there is cited essay in a book, nothing like fleshly lust. What a weakly thing is this heart of ours. Though a perfume, for ap literature essay, example, is works essay book, but a transient thing, and montana, though he knows full well that incense is burned to give an odor to garments, yet a man's heart will always be stirred by a vague perfume. The Magician of Kume, the legend runs, lost his magic power through looking at a maiden washing clothes. This may well have been, for here was no charm from without, but the real beauty of plump and glistening limbs. 8 It is well for works cited essay in a, a man to scribd be frugal, to abstain from mla format cited essay in a book luxury, to possess no treasure nor to covet this world's goods. Since olden times there has rarely been a sage who was wealthy. 9 In China there was once a man called Hsu Yu. He had not a single possession in the world. In Julius. He even scooped up water with his hands, until a friend gave him a gourd.

But one day, when he had hung it from a branch, it rattled in the wind; whereupon, disturbed by the noise, he threw it away and once more took to drinking from his clasped hands. How pure and free the heart of such a man. 10 A certain recluse, I know not who, once said that no bonds attached him to this life, and the only thing he would regret leaving was the sky. 11 A house should be built with the summer in view. In winter one can live anywhere, but a poor dwelling in summer is unbearable. Deep water does not give a cool sensation. Far cooler is a shallow running stream.

A room with sliding doors is lighter than one with doors on book hinges. When the ceiling is quiz, high the room is mla format works essay in a, cold in winter and difficult to light. As for construction, people agree in admiring a place with plenty of spare room, as being pleasing to the eye and at the same time useful for argument essay explanation, all sorts of purposes. There is a charm about a neat and proper dwelling house, although this world, it is cited essay book, true, is argument essay, but a temporary abode. Even the moonshine, when it strikes into the house where a good man lives in peaceful ease, seems to gain in friendly brilliancy. 12 The man is to be envied who lives in a house, not of the cited essay book modern, garish kind, but set among venerable trees, with a garden where plants grow wild and yet seem to have been disposed with care, verandas and in julius caesar, fences tastefully arranged, and mla format works cited essay in a, all its furnishings simple but antique. A house which multitudes of workmen have devoted all their ingenuity to decorate, where rare and strange things from home and abroad are set out in case study hypertension scribd array, and where even the trees and shrubs are trained unnaturally—such is an unpleasant sight, depressing to look at, to mla format works cited essay book say nothing of spending one's days in there.

Nor, gazing on essay it, can one but reflect how easily it might vanish in a moment of time. The appearance of a house is in mla format works cited some sort an index to the character of dmt, its occupant. 13 Once in the month of September I passed over the plain of Kurusu and sought out a certain village among the hills beyond, when, threading my way far down a narrow moss-grown path, I came upon a lonely hut. There was never a sound to greet me, save the dripping of water from a pipe buried in mla format cited essay in a fallen leaves, but I knew that someone lived there, for sprays of chrysanthemum and ap literature open ended prompts, maple leaves bestrewed the shelf before the shrine, and Ah! thought I, In such a place a man can spend his days. Essay Book. But as I stood and gazed in wonder, I perceived in the garden beyond a great orange tree, its branches weighted down with fruit. It was strongly closed in on ap literature ended prompts all sides by a fence. This broke the spell, and I thought to myself, If only that tree had not been there! 14 It wakes one up to go away from home for a time, no matter where. Exploring and cited essay in a, rambling about the countryside you come upon a host of unusual sights in rustic spots and mountain hamlets. You get a messenger to in julius essays take letters to the capital, and you write and say Do not forget to send me so-and-so at mla format essay in a the next opportunity.'' All this is in dmt its way amusing.

Of course you have a thousand things to think of in such a place. Pleasant also to slip away and go into retreat in some mountain temple. 15 In hours of quiet thought one cannot but be overcome by longing for the past. When, to while away the long nights after folk have gone to works rest, we go through our old belongings, sometimes, as we throw away such scraps of paper as we do not want to keep, the handwriting of one who is no more, or an supernatural in julius essays, idle sketch maybe, will catch the eye and vividly recall the moment it was made. It is affecting, too, after the mla format cited essay lapse of supernatural caesar, many years, to come across the letters even of one who is still living, and to call to mla format works cited essay in a book mind the year and the occasion when they were written. The things they were wont to use have no heart, yet remain unchanged throughout the long, long years. A melancholy reflection. 16 There is no such mournful time as follows on a death. For the days of retirement a crowd of people go up together to some mountain village, into a cramped and incommodious house, and there they busily perform the offices for the dead.

So the argument essay explanation appointed time passes with unwonted quickness. The last day is pitiless indeed; for cited essay, in silence they gather together their possessions, each for himself, and go their several ways. Only when they have returned to their own homes will they begin to feel exceeding sad. Months and hana montana essay, years pass by, and still they do not forget, though, as the saying goes, the departed grows more distant every day. However that may be, they seem not to in a feel so deeply as at the time of essays, death, for now they chatter and works in a book, laugh together. The body is laid to rest upon some lonely mountainside, where the hana mourners come on rare appointed days, soon the .tablet is overgrown with moss, buried in mla format works essay in a fallen leaves, and looks in time as if none came to visit there save even storms and the nocturnal moon. There may be some who will recall the dead, and synthesising dmt, think of him with grief. But soon they themselves must pass away.

Then how can later generations grieve, who know him only by repute? After a time they go no longer to his tomb, and mla format works, people do not even know his name or who he was. True, some feeling folk may gaze with pity on in julius essays what is now but the growth of grasses of succeeding springs; but at last there comes a day when even the pine trees that groaned in essay in a book the storms, not lasting out their thousand years of life, are split for fuel, and the ancient grave, dug up and turned to rice field, leaves never a trace behind. 17 One should never make a show of having a deep knowledge of any subject. Well-bred people do not talk in a superior way even about study scribd things they have a good knowledge of. It is people who come from the country who offer opinions unasked, as though versed in all manner of accomplishments. Of course some among them do have a really enviable knowledge, and it is their air of self-conceit that is so stupid. It is a fine thing when a man who thoroughly understands a subject is unwilling to open his mouth, and only speaks when he is questioned. 18 When in the presence of a new acquaintance, to carry on works book a conversation in fragments, laughing and ap literature open essay prompts, exchanging meaningful looks with a companion who knows the works cited essay in a phrases and names of things you commonly use, makes the stranger feel as if he understood nothing—this is ignorant behavior, and a sure sign of ill breeding. 19 In the case scribd Province of Inaba there was a girl, the daughter of a certain lay priest of noble family, whose hand was asked in works book marriage by many that heard of her beauty. However, this girl ate nothing but chestnuts, never touching rice or other grain, and her parents therefore refused, saying that such an unusual thing ought not to be seen by others.

20 This is a story of the priests of the Ninnaji. They had a feast to celebrate the farewell to the world of a young acolyte about to enter the synthesising priesthood. In their revels they became drunken, and mla format works cited essay book, the acolyte, beginning to feel merry, took a three-legged iron pot that lay nearby and put it on his head. Then, though it fitted very tight, he flattened out argument, his nose, pulled the pot over his face, and in a, began to essay dance. The whole company grew merry beyond measure, until after performing awhile, he at length tried to pull it off—but in vain! This sobered the feast, and they were thrown into confusion and doubt, wondering what they should do. While they were debating, the pot cut into cited in a his head, and blood began to flow and his face swelled up so that he could hardly breathe.

They tried to break it, but it was not easily broken, and as the force of the blow went to his head, he could not bear it, and they were obliged to stop. They did not know what to do next, so, throwing a black gauze cloak over the three legs, which looked like horns, they led him, supported by ap literature essay a staff, to the house of a physician in mla format book Kyoto. People looked at them with amazement as they went along. It must have been a queer scene when they brought him face to face with the open prompts physician on entering his house. When he spoke, his voice was muffled, and mla format works essay, resounded so that they could not hear what he said. The physician said that he had never seen such a case in the books, nor had he ever had any oral instruction on the point, so they were obliged to return to the temple. Essays. There his friends and relatives, with his old mother, gathered at his bedside and mla format works in a book, wept and grieved—not that they thought he could hear! At last someone said, Suppose he does lose his ears and nose, so far as living goes there is no reason why he should not survive.

Let us then pull the thing off by explanation main force. So they thrust rice straw all round between his head and the metal, and pulled as if to drag off his head. His ears and mla format, nose were torn away, and he escaped with his bare life, suffering afterward many a long day. 21 Are we only to look at flowers in full bloom, at the moon when it is clear? No, to look out on the rain and long for the moon, to argument draw the blinds and not to be aware of the passing of the spring—these arouse even deeper feelings. There is much to be seen in young boughs about to flower, in gardens strewn with withered blossom. Men are wont to regret that the works cited in a moon has waned or that the essay blossoms have fallen, and mla format essay in a book, this must be so; but they must be perverse indeed who will say, This branch, that bough is withered, now there is nothing to see. In all things it is the beginning and end that are interesting. The love of men and women—is it only when they meet face to argument explanation face? To feel sorrow at an unaccomplished meeting, to works cited in a book grieve over elements empty vows, to spend the long night sleepless and alone, to yearn for distant skies, in a neglected house to think fondly of the past—this is what love is. Rather than to see the moon shining over thousands of miles, it sinks deeper into the heart to watch it when at last it appears toward the works cited essay dawn.

It never moves one so much as when seen in gaps between the trees, pale green over the tops of the cedars on argument explanation distant hills, or behind the clustering clouds after showers of rain. When it shines bright on mla format in a the leaves of oak and evergreen, and they look wet, the in julius caesar sight sinks deeply into one's being, and one feels Oh! for a friend with whom to share this! and cited essay, longs for the capital. And must we always look upon the moon and study scribd, the blossoms with the essay in a eye alone? No, in the very thought of it, in the spring though we do not go abroad, on moonlit nights though we keep to our room, there is great comfort and delight. 22 A well-bred man does not show strong likings. His enjoyment appears careless. It is rustic boors who take all pleasures grossly. They squirm and struggle to get under the blossoms, they stare intently, they drink wine, they link verses, and at last they heartlessly break off great branches. They dip their hands and feet in springs; they get down and step on the snow, leaving footmarks; there is nothing they do not regard as their own. As soon as we hear a person's name we form in our minds a picture of his appearance; but when we come to see him, he is never the man whose face we had imagined. I suppose we all feel, when we hear stories of synthesising, ancient times, that the houses were more or less the mla format same as people's houses nowadays, and think of the people as like people we see about ap literature open ended essay prompts us.

And am I alone in having sometimes within me a feeling that words I have just heard, or things I have just seen, have happened once before? When, I cannot recollect, but none the less they certainly have happened. 23 A man who would be a success the world must first of all be a judge of moods, for untimely speeches will offend the ears and hurt the feelings of others, and so fail in their purpose. Works Essay In A Book. He has to beware of such occasions. But falling sick and argument, bearing children and dying—these things take no account of moods.

They do not cease because they are untimely. Works Cited Essay. The shifting changes of birth, life, sickness, and death, the real great matters—these are like the surging flow of a fierce torrent, which delays not for an instant but straightway pursues its course. And so, for both priest and layman, there must be no talk of synthesising dmt, moods in things they must needs accomplish. They must be free from this care and that, they must not let their feet linger. It does not turn to mla format cited in a summer after spring has closed, nor does the fall come when the case hypertension summer ends.

The spring ahead of time puts on mla format in a a summer air, already in the summer the fall is abroad, and soon the fall grows cold. In the synthesising dmt tenth month comes a brief space of spring weather. Mla Format Cited Essay Book. Grass grows green, plum blossoms bud. So with the falling of leaves from the trees. It is not that the trees bud, once the leaves have fallen, but that because they are budding from explanation beneath, the leaves, unable to withstand the strain, therefore must fall.

An onward-urging influence is at work within, so that stage presses on stage with exceeding haste. This again is exceeded by the changes of birth, age, sickness, and mla format cited essay book, death. Case Scribd. The four seasons have still an appointed order. The hour of death waits for mla format cited book, no order. Death does not even come from the front. Synthesising Dmt. It is essay, ever pressing on from behind. All men know of death, but they do not expect it of a sudden, and it comes upon open ended prompts them unawares.

So, though the dry flats extend far out, soon the tide comes and floods the beach. Adapted from The Tzuredzure gusa of Yoshida no Kaneyoshi translated by works in a book George Sansom. Asiatic Society of Japan Transactions, 39, 1911. A longer extract is printed in Anthology of Japanese Literature compiled and edited by Donald Keene. Open Ended Essay Prompts. Grove Press New York 1955.

Introduction and selection of extracts Copyright © Rex Pay 2003.