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Retrieved from http://www.url/ on canadian aboriginal rights Year, Month Date. Readers and writers alike can find headings as a useful tool in writing. Aside from providing order, essay headings can function as an ID – in the sense that it can provide identification on the ideas that are presented below. Headings function as a guide for your readers, as it will clue them in on science related your thought flow. Bournemouth. The APA style allows five levels of science papers headings when writing. Level one is the theme, first category, while the subsequent levels are provisions for succeeding sub-categories.
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monopolies essay Published July 12, 2016. Economists overwhelmingly agree that the actual costs of science research papers, monopoly are small, even trivial. This consensus is based on a theory that assumes monopolies are well-run businesses that limit their output in order to drive up prices and maximize profit. And because empirical studies have found that monopolists do not restrict output or raise prices by very much, most economists have concluded that monopolies inflict relatively little harm on the economy. In this essay, I review recent research that upends both the theoretical and i sing the body thesis empirical elements of this consensus view. 2 This research shows that monopolies are not well-run businesses, but instead are deeply inefficient. Monopolies do drive up prices, as conventional theory suggests, but because they also reduce productivity, they often ultimately destroy most of an industry’s profits. These productivity losses are a dead weight loss for the economy, and far from trivial. The new research also shows that monopolists typically increase prices by using political machinery to limit the output of science related, competing productsusually by blocking low-cost substitutes. By limiting supply of these competing products, the monopolist drives up demand for its own.
Thus, in contrast to conventional theory, the how to essays, monopolist actually produces more of its own product than it would in a competitive market, not less. But because production of the substitutes is restricted, total output falls. The reduction in productivity exacts a toll on all of society. But the blocking of low-cost substitutes particularly harms the poor, who might not be able to science related research afford the monopolist’s product. Thus, monopolies drive the poor out of many markets.
In this essay, I first review the standard theory of monopoly that contends it inflicts little harm, and then I introduce a new theory that refutes that view. In this new theory, groups within monopolies act as both adversaries that reduce productivity and allies that eliminate substitutes. The new theory thus demonstrates that monopolies in fact cause substantial economic harm, and binding dissertation bournemouth that harm falls disproportionately on science related papers people with fewer financial resources. I then provide several historical examples of monopolies from my own research and that of others. How To Do Dbq? I’ll discuss monopoly subgroups in their role as adversaries in the sugar, cement and construction industries. I’ll discuss monopoly subgroups acting as allies in the dental and legal industries. But I want to emphasize that in all monopolies, subgroups engage in both roles. I’ll also take a fresh look at a familiar example of a monopoly, U.S. Steel, showing how subgroups acted as both adversaries and allies.
These few examples are illustrative only and provide a narrow glimpse of a far broader economic phenomenon: Monopolies are prevalent in the U.S. Research Papers? (and international) economy. The conclusion summarizes this analysis and provides historical perspective for future efforts. In the standard theory of monopoly found in theme, textbooks, the monopolist is a single seller of related papers, a good who increases his or her price above competitive levels, leading to reduced output. The key cost of english science technology, monopoly is the restriction of industry production. Two basic assumptions, or tenets, underlie this theory. One assumption is that monopolists produce efficiently and maximize profits. This tenet is based on logic, not evidence. Nobel Laureate George Stigler 3 provides one rendition of related, this logic: “The goal of efficiency is pervasive in economic life, where efficiency means producing and selling goods at the lowest possible cost (and therefore the largest possible profit). This goal is sought as vigorously by monopolists as by competitors” (1988, pp.
162-63). Another assumption is that monopolists have close substitutes. This tenet is primarily based on logic, not evidence. Again, Stigler makes the case, arguing that “it is virtually impossible to eliminate competition from economic life. If a firm buys up all of its rivals, new rivals will appear. If the state gives away monopoly privileges there will emerge a strong competition in the political area for these plums” (1988, p.164). The consensus view that monopolies inflict little actual damage on society has dominated the economics literature since the seminal work by essays University of Chicago economist Arnold Harberger (1954).
Applying the standard model to science related research historical data, he calculated that monopolies do not restrict output or drive up prices by the body electric thesis very much, so that their actual costs are small. This quickly became the accepted view. But the primary source of support from economists comes not from the empirical results, but from the related papers, theory’s compelling logic. In the following sections, the logic and empirical results are challenged by i sing the body electric thesis a new view. There is a key implicit assumption buried in the standard theory of monopoly. Not only are monopolists single sellers, but they also produce the goods by related research themselves . That is, the monopolist (and perhaps clones or mindless automatons) staffs all of the machines, all of the phones, all of the a book title in an essay, processes involved in producing the good. Stated differently, in this abstraction, there are no heterogeneous groups comprising various individuals or interests and, hence, no frictions that might lead to low productivity.
Monopolists have every incentive to be productive (as do their clones or automatons). This implicit abstraction of monopolies being one-person operations has led the economics profession to miss very significant problems with monopoly. Close study reveals that monopolies are in fact composed of many subgroups, and it is the interplay among these groups that leads to low productivity and the elimination of substitutes. Sometimes these subgroups have interests that do not align, and they act as adversaries . Sometimes their interests align well, and they act as allies . When a monopoly forms, it stops competition from the outside. But this naturally leads to significant competition inside the monopoly, as subgroups fight among themselves over new opportunities afforded by the monopoly. That is, subgroups act as adversaries , and science papers this often reduces productivity. This competition among subgroups within the essays, monopolyfor better pay, working conditions or decision-making poweroften threatens to tear the monopoly apart.
To survive, the papers, subgroups agree to find ways to how to limit internal competition. Mechanisms are introducedcall them competition-reducing mechanismsthat enable subgroups to credibly commit to related research papers not compete. An example might include a worker subgroup demanding a work rule that forbids other workers from performing “their” particular task. But these mechanisms come at a high cost: reduced productivity. English Science? The standard assumption that monopolies are efficient producers is undermined. But the new view of monopoly contains another key element: monopolist subgroups acting as allies to eliminate substitutes from competitors external to the monopoly. Related Research? Consider the logic of close substitutes. Politically adept monopolies (as they are de facto since the large majority of monopolies result from special privileges granted by the government) often use their political influence to weaken or destroy existing substitutes for their product.
Entrepreneurs may be well aware of the monopolist’s political power and thereby be discouraged from developing substitutes. Lastly, imagine what types of for sale, substitutes a monopoly might try to weaken or eliminate. It would not go after those with broad political support. Rather, it would target those with little support, those purchased by politically disadvantaged low-income segments of the population. A few examples of related papers, monopolies that reduce productivity and i sing the body electric thesis kill substitutes. As just mentioned, subgroups within monopolies act as adversaries and science related papers allies. Adversarial relationships often reduce a monopoly’s productivity substantially. When subgroups act as allies, their joint goal is theme seo tutorial, often to eliminate products that might otherwise compete with theirs. While subgroups in any monopoly engage in both adversarial and cooperative actions, I’ll discuss separate examples of science related research, each in punctuate title essay, this section. Adversaries: Reducing productivity.
I’ll start by looking at related papers, some adversarial relationships. In the United States, the sugar cartel, cement industry and i sing electric thesis construction business provide excellent examples of subgroups within monopolies acting as adversaries and reducing productivity. During the Great Depression, the science papers, sugar manufacturing industry was one of many industries permitted to form a cartel as part of New Deal economic policy (see Bridgman, Qi and a book essay Schmitz 2015). In exchange for this permission, the industry agreed to sell sugar at a “fair” price. In addition, members of the industry, including factory owners and science related research papers incumbent farmers, drafted a joint plan (subject to binding dissertation government approval) for science related research papers, how the binding bournemouth, cartel would meet price targets and share cartel profits. Science Related Research? The cartel allocated sales quotas to factories each year so as to hit the agreed-upon price target, a price in line with the agreement with the federal government. English? This cartel operated from 1934 to 1974.
There were many adversarial relationships within the science related research papers, sugar industry that led to cartel rules beyond the factory sales quotas. These additional rules greatly lowered productivity, as well as productivity growth. One such example: conflict between farmers and factory owners. Just as factory owners wanted and theme seo tutorial received sales quotas, farmers demanded and got quotas on related papers the number of acres used to grow sugar crops. The acre quotas were not a mechanism to control sugar prices; the factory sales quotas served this purpose. Rather, they were a mechanism to ensure that incumbent farmers received a share of the monopoly profits. Without the acre quotas, for example, firms could have moved their factories beyond the geographic range of thesis, incumbent farmers.
It was this adversarial relationship between factories and farmers that led to acre quotas. Sugar-producing states were also locked in adversarial relationships, most notably by “stealing” manufacturing industries from each other, a common practice that goes back to the late 1800s. So some cartel subgroups, in particular, local and state authorities, had the incentive to push for limits on the renting of quotas, whereby acre quotas could be traded only science related research, within counties. Ultimately, they succeeded in including such rules in the cartel agreement. These cartel rules led to electric large productivity losses.
When the cartel was started in 1934, California and Colorado were the biggest beet-sugar-producing states, while Minnesota and North Dakota were very small producers. After World War II, the opportunity cost of research papers, land and science essay (irrigated) water in Colorado and research papers California grew much faster than in, say, Minnesota and North Dakota. Because cartel rules prohibited farmers from renting their quotas beyond the local area, however, quota rights could not flow from, say, California to theme North Dakota, where additional acres would have been more profitable. The result was tremendous inefficiency, as the opportunity cost of inputs used to science produce a given quantity of sugar in California was much greater than that in North Dakota. The same thing happened where sugar cane was grown. When the sugar cartel started, Louisiana was a large cane producer, but Florida had barely begun its cane crop, and so received a very small quota. After WWII, the profit of the science technology, marginal farmer in Florida began growing much faster than that of his or her counterpart in research papers, Louisiana but, again, quotas could not move to Florida, where production would have been more profitable. Quotas also led to slower productivity growth by binding bournemouth eliminating the incentive to find ways to increase output by, for example, increasing the period during which factories can operate during the year. Indeed, the sugar industry’s factory-operating days have increased dramatically in the United States since the cartel ended. The U.S. cement industry provides another good case study of papers, adversaries within a monopoly. 4.
During the ready essays, 1950s, a powerful union, the United Cement, Lime and Gypsum Workers International Union (CLGW, for short) had a near-monopoly on science the supply of labor to the industry. Again, there were many adversarial relationships among subgroups. One was between different groups of workers. Because the workers were earning very high wages, there was potentially severe competition for jobs. Hence, groups of how to, workers fought for rules that would secure their jobs from related, competition from other workers. For example, union contracts had rules such as: “When the Finish Grind Department is completely down for science essay, repairs, the Company will not use Repairmen assigned to science the Clinker Handling Department on the body thesis repairs in the Finish Grind Department.” 5 No detailed knowledge of cement plants is needed to understand that this rule was meant to protect the repair jobs in the Finish Grind Department. This rule enabled workers to credibly commit to not compete with each other. This rule, and many others like it, not only protected jobs, but led to underutilization of papers, capital. 6 Such rules led to a waste of resources, like energy.
7 Such mechanisms, sometimes called restrictive work practices, led to significant reductions in industry productivity. Other restrictive work practices resulted from adversarial relationships between workers and the body electric thesis managers. Science Papers? After the CLGW negotiated a big wage increase in the early 1960s, managers invested in dissertation, larger, labor-saving machines that led to significant job losses. Science Research Papers? Unions reacted by demanding a 1965 rule that prohibited managers from firing workers made redundant as a result of new investment, new ways of organizing production and so on. Managers agreed to the union demand, but this restrictive work practice significantly reduced productivity. One would expect this rule to have dulled investment incentives and, indeed, there is evidence of a dip in ready essays, investment in the late 1960s. But the science research, energy crisis of the 1970s hit the cement industry hard, and the industry responded by making big investments in english science technology, new, energy-efficient machinery. Science? The new machines were also more labor-efficient, but managers abided by their earlier commitment not to reduce employment. Hence, large productivity gains were repeatedly sacrificed to how to a book title in an essay preserve peace between adversaries. When foreign competition rocked the industry in the 1980s, the landscape changed. Cement factory managers were no longer committed to the rules they had agreed to with the CLGW.
The industry was able to expand its output and reduce its workforce; labor productivity soared. Science Research? The gains that were missed in the 1970s were enjoyed in the 1980s. Construction: Size is not the i sing the body electric thesis, issue. Discussion of monopoly typically conjures up images of giant corporations and giant manufacturing establishments, like U.S. Steel and related its massive factories. But, in for sale, fact, the size of the monopolist’s operation does not correlate with its destructive impact. Monopolies consisting of small units, operating on a small scale, also do great damage. 8. Judge Kenesaw Mountain Landis found this to be true 90 years ago in dealing with the Chicago construction industry. He described an industry in turmoil: “It is the violation of no confidence to say that building construction has gotten into bad repute in this community.
There was a general disposition to keep away from it as a thing diseased. Capital avoided it. The wise dollar preferred almost any other form of science research, activity or no activity” (Montgomery 1926, p. English Science Technology Essay? 273). To address these serious problems in Chicago construction, Landis was appointed to arbitrate wage disputes (Montgomery 1926). But Landis felt that if he was to do his job well, he needed to also analyze the work rules in the industry. This surprised and scared most of the science related papers, parties involved. Landis also knew that the essays, work rules contained in the contracts were the science research papers, tip of the iceberg, so he spent a considerable amount of thesis theme, time going out to jobs, talking with the workers and investigating the situation firsthand (p. 270). Papers? He concluded that while high wages were an issue, “The real malady lurked in dissertation bournemouth, a maze of conditions artificially created to give parties a monopoly, and in rules designed to produce waste for science papers, the mere sake of waste; all combined to bring about an insufferable situation, not the least burdensome element of which was the essays, jurisdictional dispute between trade-union members of the same parent organization” (p. 273). The waste he reported is with us still (Schmitz 2016).
I can also apply these ideas to nonindustrial markets not usually thought of as pervaded by monopoly, such as the markets for professional services. Although these markets are made up of thousands of independent professionals, these professionals band together to act as a cartel, a monopoly composed of related, many separate business entities. I will show that the problems of monopolylow productivity and the elimination of low-cost substituteshave permeated these markets as well. Indeed, the essays, problems created by these monopolies are particularly pernicious because they limit the supply of low-cost substitutes for high-priced professional services. For example, lawyers limit the provision of inexpensive legal advice by paralegals, and dentists limit the provision of low-cost fillings by dental therapists. These limitations are not too harmful to science related papers the rich. How To Do Dbq? But for those with low income, such restrictions make legal advice and related research papers dental care unavailable.
They are priced out of the market. Again, the costs of monopoly are inflicted disproportionately on the poor. Subgroups in a monopoly are not necessarily adversaries. Indeed, they may act as allies when they try to eliminate competition from substitute products. Consider, for for sale, example, the dental industry. There are many thousands of dentists, but they coordinate their actions through state dental associations. While these associations may have some public benefit, such as continuing professional education, they also act like a cartel, finding ways to increase the price of their members’ services. Papers? They do so in a way that also increases the demand for their services. One service dentists provide is technology essay, filling cavities. In many countries, dental nurses or dental therapists, as they are called, are trained to provide these services, most often in school-based programs for children. 9 In the United States, dental therapists have been vigorously opposed by dentists, with a few exceptions, including the native villages of science research papers, Alaska and the state of Minnesota.
The impact of these cartel restrictions is profound. English Technology Essay? Dental therapists require less training than dentists and so are able to provide basic services at a lower cost. Blocking these mid-level providers significantly increases the price of science related research, filling cavities, and low-income people may be forced to the body electric thesis go without basic dental care. The debate over research papers dental therapists in the United States is not over. Since Minnesota authorized the licensure of dental therapists in 2009, Maine and Vermont have passed similar laws.
A number of states are considering similar measures, despite stiff opposition from state dental associations. The laws often require that dental therapists work under the direct supervision of technology, dentists, ostensibly for the protection of science research, patients, but the arrangement also protects dentists from how to essays, competing directly with dental therapists operating independently. In most health markets, monopolies restrict or kill low-cost substitutes. For example, in the hearing aid industry, audiologists, who have Ph.D.s, often put tremendous entry restrictions on hearing aid fitters. The fitters are less skilled, but are perfectly capable of research papers, most work.
Again, the essays, poor are hurt by this. This same analysis applies to many other types of services. Lawyers introduce statutes to science research prevent the “unlawful practice of dissertation, law.” Essentially, lawyers don’t allow anyone who is not a member of the bar to provide legal advice, so paralegals are not allowed to operate independently. Science Related? Again, low-income people suffer the most from lack of access to lower-cost alternatives. In the construction industry, unions block the use of preassembled parts on construction sites. This eliminates a close substitute: factory assembly. Again, this hurts the poor the most, as they buy houses that use such materials. Schmitz (2016) provides many more industries and much more analysis. Adversaries and allies: Low productivity, few substitutes.
U.S. English Science Essay? Steel is often cited as a classic example of science research, a monopoly. The company controlled a large share of the steel business and used this control to drive up prices. But it is also a good example of the new theory, illustrating the thesis theme seo tutorial, bigger picture of the costs its monopoly imposes on the economy. The monopoly’s subgroups act both as adversaries that reduce productivity and as allies that eliminate competition from science, substitute products. The U.S.
Steel monopoly was composed of many subgroups, including shareholders, managers and hourly employees, as well as the United Steel Workers of America, the union that organized the bournemouth, entire steel workforce. I’ll sometimes refer to the monopoly as the USS-USW monopoly. In some settings, these groups were fierce adversaries. In others, they were strong allies. Consider their adversarial roles. Given that the monopoly was generating significant profits, at papers, least at first, subgroups had an incentive to increase their share of the pie and certainly to protect their share from other subgroups. The subgroups developed mechanisms to protect their share of profits, mechanisms that essentially committed the technology essay, groups to not compete with each other.
Unions and management agreed on restrictive work rules that helped to protect jobs, but led to inefficient production. Executives ignored technological innovations, such as continuous casting of steel, that could have produced steel at much lower cost, but would have disrupted the bargain between the firm and its workers. All of these compromises between adversaries harmed the related, company’s productivityand because the company so dominated the steel industry, the entire industry was less productive as a result. Next consider the subgroups in dissertation, their roles as allies. The competitive vacuum that allowed the USS-USW monopoly to survive while being unproductive was no accident. Indeed, it was a situation that USS-USW worked hard to create and maintain. The issue is not merely that U.S.
Steel bought up and related research maintained control of competing steel companies within the United States, as monopolists always do, or that the USW successfully organized the entire steel workforce. If subgroups USS and USW had done only thesis seo tutorial, those two things, they still would have faced significant competition from research, foreign firmscompetition that would have forced them to raise productivity and take on new, better technology. But USS-USW used its political clout to lobby for tariffs that protected it from foreign competition. That is, U.S. Steel worked to restrict the output of binding dissertation bournemouth, foreign steel, a close substitute for science related research papers, steel made domestically. These restrictions meant that the demand for domestic steel was higher than it would have been otherwise, allowing U.S. Steel to increase its output, even as it increased prices. These artificially inflated prices injured any U.S. buyer of steelbe it a car manufacturer or an oil drillerand ultimately hurt the consumer. For decades, the theoretical understanding and empirical analysis of monopoly have themselves been monopolized by a dominant paradigmthat the costs of monopoly are trivial.
This blindness to new theory and analysis has impeded economists’ understanding of the actual harm caused by monopoly. Rather than inflicting little actual damage, adversarial relationships within monopolies have significantly reduced productivity and economic welfare. And in many industries, subgroups within monopolies collaborate to eliminate competition from low-cost substitutes. This lack of competition in binding, the marketplace has a disproportionate impact on research poor citizens who might otherwise find low-cost services that would meet their needs. I’ve described this as a “new” theory, but in truth its roots go back decades, to the ideas of Thurman Arnold. Arnold ran the i sing the body thesis, Antitrust Division at the Department of Justice from 1938 to 1943, taking aim at a broad range of targets, from related research papers, automakers to ready essays for sale Hollywood movie producers to the American Medical Association. 10 He argued that lack of competition reduced productivity and that monopolies crushed low-cost substitutes, hurting the poor.
Arnold supported his arguments through intensive real-world research. He and his staff undertook detailed investigations of monopolies, examining the on-site operations of related, many industries and documenting the productivity losses and ready destruction of substitutes caused by monopoly. Arnold began his work at a pivotal timein the science research, midst of the Great Depression, just after the United States had experimented with the cartelization of its economy. How To A Book Essay? Faith in competitive markets had reached such a low that cartels and monopolies were thought to be, perhaps, better alternatives. His work and science research papers ideas played a big role in reinvigorating confidence in competitive markets. A Book Title In An? He mounted an aggressive campaign to protect society from research, monopoly. The campaign had two parts: forceful prosecution of monopoly through the courts, accompanied by an array of speeches and articles to educate the binding bournemouth, general public about its costs.
Economists gradually forgot Arnold and science related his ideas, convinced by Harberger’s empirical work and the introspection of how to punctuate in an essay, economists, leading to, for example, the logic provided by related research papers Stigler and others. Scholars and regulators who studied monopolies focused on prices alone and found little to worry about. But as shown by the research reviewed in this essayand an expanding body of empirical workthe problems caused by monopoly are significant, and binding dissertation still pervasive. Related? My hope is that this paper will open a new era of discussion about monopoly and its costs, and ultimately lead policymakers to encourage greater competition for the benefit of all. 1 The author thanks Ann Harrington for her valuable suggestions on the content and organization of how to, this essay. The views expressed here are those of the author, not necessarily those of related research papers, others in the Federal Reserve System. 2 Schmitz (2016) contains more detailed discussion and references to thesis seo tutorial the material in this article. 3 Stigler (1988) presents the familiar logic behind this assumption.
4 The history of this industry, and the rise and fall of monopoly in it, is papers, beautifully described in Northrup (1990). A quantitative analysis, on how to do dbq essays which the following discussion is based, can be found in Dunne, Klimek and Schmitz (2016) 5 Quoted from the Voice (Oct. 1978, p. 86), a monthly publication of the science related research, CLGW union. 6 Machinery in the Finish Grind department was idle (broken) for longer than was necessary. Machines in other departments also may have had to be slowed.
7 Kiln fuel was being burned even if the plant was not able to bournemouth produce cement. 8 For Thurman Arnold, who directed the Antitrust operations of the Justice Department from 1938 to science research papers 1943, size was not the decisive factor in determining a monopoly, but whether the monopoly reduced efficiency. Bridgman, Ben, Shi Qi, James A. Schmitz Jr. 2015. “Cartels Destroy Productivity: Evidence from the New Deal Sugar Manufacturing Cartel, 1934-74.” Federal Reserve Bank of Minneapolis Staff Report 519. Dunne, Tim, Shawn Klimek, James A. Schmitz Jr. 2016. “Monopoly Stifles Productivity, Competition Spurs It: Evidence From Post WWII U.S. Cement Manufacturing.” Federal Reserve Bank of Minneapolis Staff Report, forthcoming. Harberger, Arnold C. 1954. “Monopoly and Resource Allocation.” American Economic Review 44 (2): 77-87. Kolasky, William. 2013. “Thurman Arnold: An American Original.” Antitrust 27 (3): 91-92.
Montgomery, Royal E. Theme Seo Tutorial? 1926. Related Papers? “The Landis Arbitration and Award.” University Journal of Business (University of Chicago Press) 4 (3): 260-93. Northrup, Herbert R. 1990. “From Union Hegemony to thesis theme Union Disintegration: Collective Bargaining in Cement and Related Industries.” Journal of papers, Labor Research 11 (3): 360. Schmitz, James A. Binding? Jr. 2016. “The Costs of Monopoly are Large and Inflicted Disproportionately on the Poor.” Federal Reserve Bank of Minneapolis Staff Report, forthcoming. Stigler, George J. 1988.
Memoirs of an Unregulated Economist . University of Chicago Press.
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Toronto Rotman 2015 MBA Essay Tips and Deadlines. The University of Toronto’s Rotman School of Business is research papers, one of the leading business schools in Canada. Known for its design approach to MBA education and strong emphasis on problem solving, Rotman’s program is growing in size and renown. My tips are in blue below. 1. Please state your professional goals and how you plan to achieve them. (Please limit your answer to 25o words.) This is a pretty straightforward goals question, requiring a concise answer. What do you want to do and where do you want to do it? The “where” refers to how to punctuate essay, industry, not necessarily geography, but geography could be a part of your goal. Science Papers! If it is, you should include it in your response. Your essay should show Rotman that you have thought about your career path, Rotman’s role in that chosen path, and how your career can realistically progress after you receive your Rotman MBA.
2. Describe the most important piece of constructive feedback you have received recently. Please detail the circumstance and your plan to address it. (Please limit your answer to 25o words.) Tell a brief story here. What were you told? What was the context? How has it proven constructive? If you have room in your essay and you feel it fits with the rest of your response, include a situation similar to the one that prompted the criticism and that you handled well as a result of the a book in an essay advice you received. Alternatively, you could even start with the situation that ended well, and then provide the science related papers background, including the story of the constructive feedback. 3. The Body Electric Thesis! Reflection Question: List 3-5 attributes or characteristics that best describe you. Limit response to 50 characters. (3-5 word maximum.) My suggestion here would be to related papers, avoid what my friend and colleague from Maxx Associates, Maxx Duffy, calls “umbrella words.” These are general terms for valued attributes, but they tend to be abused and overused in the MBA application process.
There is nothing wrong with them other than the reality that they are sapped them of how to punctuate title essay, meaning and impact. And if you use these umbrella words, you will blend in with all the others who are also using them, just like one more black umbrella on papers, a rainy day. An example: leadership. I guarantee that attribute (or any form of “lead”) will be the thesis theme most commonly mentioned term. Science Related! I encourage you not to use a form of “lead” or “leader.” It is an punctuate a book title in an, umbrella word. Instead, go into the key attributes you have that make you a great leader.
Those are the qualities that go under the umbrella. They will be more distinctive and more memorable. The video interview component is a required part of Rotman Admissions process designed to give all candidates guaranteed “face time” with the Admissions Committee and showcase your personality, characteristics, passions, and values. You will have an opportunity to test the technology, and then will be asked two taped questions. Both questions are personality/values based and are designed to be answered without any advanced preparation and will only take a few minutes to complete. After completing your questions, you will receive a confirmation email and unique URL to input into this section of the science papers application and complete the video component. Good luck and have fun with the process! We’ve written blog posts on the video essay, and last year I had a fascinating interview with Niki da Silva, Rotman’s Admissions Director, who provided excellent advice on the Rotman video interview. It is by do dbq, far, our most popular podcast. Here are links to related papers, these resources. I want to get into Rotman 2-year full time MBA program during this application cycle.
Could you please evaluate my profile and tell me my real chance at getting into Rotman 2-year program this year? Thanks. I). Binding Dissertation! Full-time Work Experience. Postgraduate: 0 year, 0 month.
During College: 1 month, paid, full time, from science research papers July 2011 – August 2011. I was once selected, through a selection tryout, by the Ministry of Education of Taiwan to serve as an administrative assistant in an one-month, experimental English training program. The program was hosted by the Ministry of thesis theme, Education of Taiwan and supported by ETS Taiwan. My duties were to help prepare training materials and to conduct administrative miscellaneous tasks. 2nd attempt, on papers, Dec 22, 2014.
Total 750, 98% || Verbal 40, 91% || Quant 51, 97% || IR 7, 81% || AWA 4, 21% 1st attempt, on theme seo tutorial, Nov 20, 2014. Total 670, 83% || Verbal 32, 66% || Quant 49, 79% || IR 8, 92% || AWA 4, 21% Institute: National Taiwan University of Science and Technology (NTUST) – Top 6 in Taiwan, Top 25 in the Greater China Region, according to QS THE. – Top 1 among the papers 57 technical universities in Taiwan, according to QS THE. Degree: Bachelor of Arts, received on english science essay, June 2014. – Major: Applied foreign languages (English, linguistics, interpreting, translation) – Minor: Finance, an interdepartmental 24-credit program.
Average Overall: 88.24/100 (Converted CGPA 3.79/4.00) Average Final Year: 92.33/100 (Converted CGPA 3.92/4.00) – Grading descriptions: 60 = Pass, 60-69=C, 70-79=B, 80-89 =A, 90-100=A. Graduate Rank in the department: 4/28 (14%) On President’s List X 4 times. -awarded to students whose academic averages are among the research papers top 10% highest in dissertation the department in the semester. VI). Extracurricular Activities Leadership. 1. Founder President, NTUST Model United Nations Society.
– established the club from science related research papers scratch, the first club of this nature at thesis my university. – chaired and organized a mini Model UN conference on science research papers, campus every week. – led the club to thesis, attain a recognized status in 4 months. – captained a 6-people team to the Pan Aisa Model UN 2012 in science related research papers Taipei. – captained a 3-people team to the Harvard World Model UN 2013 in punctuate a book title in an Melbourne. – coordinated diverse members: among the research 25 members, 11 were international students from countries such as Indonesia, Russia, PRC, India, etc. 2. Initiator Lead Organizer, 2014 Sunflower Student Movement NTUST.
– formed a temporary student coalition at my school to echo the Sunflower Student Movement in ready essays for sale Taiwan* – initiated and organized a 500-people seminar on related issues. – initiated and science papers, organized a 70-people discussion forum on extended issues. – launched a campaign to raise people’s awareness on punctuate a book title in an essay, the issues. – launched a campaign to petition faculty members at my college not to science, take the rolls for how to in an two weeks when thousands of students in science related papers Taiwan staged large-scaled sit-ins at the legislature buildings. *Sunflower Student Movement in Taiwan was a student movement provoked by ready essays, the exposed secret treaty between Beijing and science related research papers, the pro-Beijing Ma government of Taiwan, a treaty that might sacrifice Taiwan’s de facto sovereignty,national security, and democracy only in technology essay return for related papers a closer relationship with Beijing. Mass demonstrations were ignited after Ma’s party declared the treaty bill passed even without a legislature vote on the bill.
3. Student Representative, Students’ Representative Council NTUST. (a) review and vote on bournemouth, the student government officer appointments. (b) review and vote on papers, the student government budgets. (c) advise and vote on the activity proposals. (d) impeach student government officers. (e) introduce and vote on any change to the student governance charter. VI). At college, I enrolled in an interdepartmental minor program in finance. Now, I want to deepen my knowledge on the body, finance in a finance center and sharpen my real game strategy-making skills by interacting with experienced leaders. I think Rotman is an ideal place to satisfy these needs.
If successfully admitted into and graduated from science research papers Rotman, I would like to make best of the immigration work visa policy to stay at thesis theme Toronto and compete for a decent job in the Toronto finance industry. Also, I expect to pass CFA 2 or 3 after graduating from Rotman, although I just have limited knowledge on finance now. VII) Excuse for gap 6-months. I graduated from college in late June 2014 (near July). After that, I didn’t attempt to find a job but instead decided to spend three or four months traveling around my country Taiwan, taking some rest, and science research, re-thinking about my plan for future. Soon, it was around November.
Then, I thought it was time to how to punctuate title in an essay, work on GMAT, so I spent around two months on GMAT. Science Related Research! Then, it was Christmas. … … 6 months just passed. Thank you very much for your patience. Hello, Thank you for the information. Ready Essays! I’m just curious, are the essay questions you provided above the actual questions for this year’s application? Will applicants be given the questions beforehand and have a few days to prep for both the written and video essay?
Thank you very very much. If any readers would like a profile evaluation for science Rotman, please provide the following info: 1) Brief description of your full-time work experience. 2) Your GMAT or GRE. Percentiles preferred. 3) College info: The name of the college, your GPA or grade average, your major, year of i sing thesis, graduation. For any graduate degrees, please provide the same info. If you grades are low, please indicate if there were extenuating circumstances.
4) Significant college and science research, post-college extra-curricular activities or community service, especially leadership experience. 5) Important certifications like CFA, CPA, FSA, or CA. 6) Your post-MBA goal. Or if you just have a question about MBA admissions, I’ll do my best to thesis, answer it. Thank you very much for assessing briefly my profile. Research! I am a young applicant with 3 years of work experience. Binding Dissertation Bournemouth! Your opinions are highly appreciated. 1) I have been working in PricewaterhouseCoopers China since October 2012, in Assurance Practice.
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I graduated in 2012. 4) 1.When in the Sun Yat-sen University, I was the team captain of the Athletics Team for thesis 2 years. Science Related Research! I got a sport scholarship from the do dbq University of science research, Hong Kong, and I was a team member of the Athletics Team there. 2. In PwC, I am an active Corporate Responsibility Champion of my company, and I have organized 2 Corporate Social Responsibility events. 3. I am a volunteer financial consultant for NGO Friends, China.
5) CFA Level III Candidate, and CICPA final stage exam Candidate. 6) I want to work as consultant in a leading consulting firm in english technology Corporate Finance Practice. Thank you very much. Thank you very much for assessing briefly my profile. I am a young applicant with 3 years of work experience.
Your opinions are highly appreciated. 1) I have been working in research papers PricewaterhouseCoopers China since October 2012, in Assurance Practice. Currently I am holding the Senior Associate title within the firm. 2) I took GRE in science technology essay 2010 (old GRE), with Verbal 580 (158), 78th percentile, Quants 800 (160), 92th percentile. 3) I graduated from Sun Yat-sen University (top 10 university in China), with one-year exchange program in the University of Hong Kong. I majored in English in related Sun Yat-sen University, and in Business Administration in the University of science technology, Hong Kong.
My overall GPA is 3.7/4. I graduated in research 2012. 4) 1.When in the Sun Yat-sen University, I was the team captain of the Athletics Team for 2 years. I got a sport scholarship from the University of Hong Kong, and bournemouth, I was a team member of the Athletics Team there. 2.In PwC, I am an active Corporate Responsibility Champion of my company, and I have organized 2 Corporate Social Responsibility events. 3.I am a volunteer financial consultant for NGO Friends, China.
5) CFA Level III Candidate, and CICPA final stage exam Candidate. 6) I want to work as consultant in a leading consulting firm in Corporate Finance Practice. You have a competitive profile for Rotman . Thanks a ton for Rotman profile pre-evaluation post, your views are greatly appreciated on papers, the subject, kindly look into the following: 1) 13 years rich experience in dissertation leading Oil Refining PSU Indian Oil. Corporation ltd (IOCL), working as Process Manager – handling from process. plants for research papers operations troubleshooting to performance reviews of do dbq, top. management and Ministry, Govt of science related papers, India. 2) GMAT: 670 ( 82%), Verbal 31(61%), Quant. 49 (78%), AWA 4.5(44%), 3) National Institute of ready, Technology, Tiruchirappalli, Tamilnadu, India.
B.Tech (Chemical Engineering) 1996-2000, Percentage 76, First class. 4) Coordinator: NIT Tiruchirappalli alumni association, Coordinator – flood relief committee, IOC Gujarat Refinery Township, Personal mentor and teacher of related research papers, 3 underprivileged children, Interests: Distance running (10k and half marathons), reading,
swimming, traveling and photography. 5) Short term: a Supply Chain Manager in leading Energy Company. Mid Term: Managing all aspects of running a plant from business. Long term: Finding a consulting firm, advising solutions for electric thesis operational. issues to Energy firms in global competitive environment. An early reply is highly appreciated. Detailed resume may be provided if required for assessment. You have a lot of experience.
A lot more experience than Rotman usually accepts. Related Papers! And ironically that is the how to title biggest weakness in related research your profile. Please see http://www.accepted.com/mba/older.aspx . The other elements are competitive for thesis seo tutorial Rotman. Thanks a lot Linda for candid feedback, I’ld keep in mind the details as per link in your reply. Is it possible I can further discuss my candidature or application services separately with you w.r.t. Science Research! canadian bschools. Choose your desired degree and then the service that best meets your needs.
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100 Easy Causal Analysis Essay Topics. VirginiaLynne has been a University English instructor for research papers, over 20 years. Essay? She specializes in helping people write essays faster and related, easier. How To Do Dbq? Causal analysis essays answer the question, Why? Many times, answer to this question can't be proved absolutely, so sometimes this essay is called a speculating about causes essay. Science Related Research Papers? To write it, you will describe what happens and then state your answer (aka thesis) about the cause, providing support for your answer with reasons and evidence. • Why do people do that? • Why does this happen? • Why is this a trend? • Why does it occur? What causes people to develop phobias? Why do some people become addicted to gambling when others can gamble and not become addicted? What causes people to rise above a disadvantaged background such as poverty, a single-parent household, or abusive parents?
What are the chemical causes of falling in essays, love? What causes feeling of romantic attraction to fade? What causes love at first sight? Why do people lose their memories as they get older? Why do people need to sleep? Why do we develop muscle memory for some repetitive actions? Why do people experience nightmares? Why do some marriages last for a lifetime? Why do we have short and long term memory?
Why do people get dyslexia? Why do we respond physically to fear? Why do we yawn (or hiccup, or stretch)? Why can people, who have their eyes closed, sense objects they are approaching but not yet touching? What makes some people introverts and others extroverts? Why is methamphetamine so addictive? Why do people crave sugar? Why do some families look so much alike, while others don't? Why do first born children tend to science related research papers be achievers? Why do people snore?
Why do people lie? Why do people blush? Why do people hate? Why do teenagers rebel against their parents? Why do teens get acne? Why do teens sleep so much? Why do teens cut themselves? Why do people commit suicide? Why do teens engage in sexting? Why do young people start smoking when they know it causes cancer?
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Why are pets good for research, kids? Why do dogs eat strange things like grass and poop? Why do cats show pleasure by purring and kneading? Why do cats like to essays for sale sleep in related research, boxes and thesis theme, other strange places? Why do cats who are well-fed still hunt? Why do birds build elaborate nests? Why do monarch butterflies migrate long distances?
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Why does English have so many words of French origin? Why is science related, English the main language used around the world in business and science? Why does India have a caste system? Why are the Chinese still interested in religion after years of binding bournemouth atheist communism? What caused the great Chinese famine in the Great Leap Forward?
What caused the black plague of the Middle Ages to stop? What caused Great Britain to related papers adopt the parliamentary system? Why does America have an educational system that is how to do dbq essays, different from the papers, European system used by most of the rest of the world? Why, according to the 2000 U.S. Census information, did more Americans identify with German ancestry (15%) than any other heritage (Irish was second at 10%, and bournemouth, African American was third at science research 8%)? Why did Japan attack the U.S. at Pearl Harbor? or Why did America drop an atomic bomb to end the war? Why is it important to study history? (Depending on how you answer, this could be worked into a causal essay topic.) After choosing your topic question, you can research online to get some ideas of essays possible answers. Related Research? Title: The causal question makes a great title for thesis seo tutorial, your essay. However, you should probably make the science related papers, question as short as possible for essays for sale, the title.
Your answer to science the question will be the thesis of your paper. Introduction: Start your introduction by interesting your reader in the topic and describing the how to do dbq, situation or effect. See the research, chart for easy introduction and i sing the body electric, conclusion ideas. The end of your introduction will be your cause question and thesis. Thesis: Start your thesis by asking your question and then answering it. To make your thesis into science, a clear roadmap of seo tutorial what you will talk about in papers, your essay, add a because followed by the three reasons you will give in the body of binding dissertation your essay.
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See ideas in how to a book title in an essay, the chart below. Easy Introductions and Conclusions. 100 Problem Solution Essay Topics with Sample Essays. by Virginia Kearney 42. Easy Argumentative Essay Topics for College Students. by Virginia Kearney 5. by science related papers, Virginia Kearney 6. How to Write a Proposal Essay/Paper. by Laura Writes 40. 100 Argument or Position Essay Topics with Sample Essays. by essays, Virginia Kearney 37. Science Papers? 100 Science Topics for Research Papers. by Virginia Kearney 108. Thesis Theme Seo Tutorial? this really helped!
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141. Intellectual Vitality Essay - Technology consulting A command window pops onto my laptop screen; “C:UsersAdmin” is written in white against a black background as I stare curiously at what this means. Just at the end of 10th grade, I applied to intern for a technology consulting firm, COMPANY_NAME. As it was a newly founded company, t. 142. Ready Essays. What matters to you, and science related research why? - Nurturing Kitties One thing that bears great importance to ready, me is research papers that those who cannot otherwise provide safety and security for themselves are given the appropriate help. To me, this matter manifested itself in the form of animals. Ever since I was little, my life was filled with the abandoned, the left behind, the . 143.
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Essay/Term paper: Diphtheria (corynebacterium diphtheriae) Free essays available online are good but they will not follow the guidelines of your particular writing assignment. Related Research Papers. If you need a custom term paper on Science Reports: Diphtheria (Corynebacterium Diphtheriae) , you can hire a professional writer here to write you a high quality authentic essay. While free essays can be traced by Turnitin (plagiarism detection program), our custom written essays will pass any plagiarism test. Our writing service will save you time and grade. Corynebacteria are Gram-positive, aerobic, nonmotile, rod-shaped bacteria. related to the Actinomycetes. They do not form spores or branch as do the. actinomycetes, but they have the characteristic of forming irregular shaped, club-shaped or V-shaped arrangements in normal growth. They undergo snapping.
movements just after cell division which brings them into characteristic. arrangements resembling Chinese letters. animal and plant pathogens, as well as saprophytes. Some corynebacteria are part. of the normal flora of humans, finding a suitable niche in thesis theme seo tutorial, virtually every. anatomic site. The best known and most widely studied species is Corynebacterium. diphtheriae, the causal agent of the disease diphtheria. The etiology, mode of transmission, pathogenic mechanism and molecular basis of.
exotoxin structure, function, and science related action have been clearly established. Consequently, highly effective methods of treatment and prevention of diphtheria. have been developed. medical microbiology, immunology and molecular biology. Many contributions to. these fields, as well as to our understanding of host-bacterial interactions, have been made studying diphtheria and the diphtheria toxin. century B.C. There are also references to the disease in ancient Syria and Egypt. In the 17th century, murderous epidemics of diphtheria swept Europe; in Spain.
El garatillo (the strangler), in Italy and Sicily, the gullet disease. epidemic proportions in 1735. Essays For Sale. Often, whole families died of the related papers, disease in a few. was cultivated by Loeffler in 1884, who applied Koch's postulates and properly. identified Corynebacterium diphtheriae as the agent of the disease. thereby provided the first description of a bacterial exotoxin. culture fluid of C. diphtheriae which, when injected into suitable lab animals,
caused the punctuate in an essay, systemic manifestation of diphtheria. with a heat-attenuated form of the toxin and demonstrated that the sera of. immunized animals contained an antitoxin capable of protecting other susceptible. animals against the disease. This modified toxin was suitable for science related research papers, immunizing. animals to obtain antitoxin but was found to cause severe local reactions in. humans and could not be used as a vaccine. neutralized by antitoxin (forming a Toxin-Anti-Toxin complex, TAT) remained. immunogenic and eliminated local reactions seen in the modified toxin. Bournemouth. For some.
years, beginning about 1910, TAT was used for active immunization against. diphtheria. Science Related Papers. TAT had two undesirable characteristics as a vaccine. First, the. toxin used was highly toxic, and the quantity injected could result in a fatal.
toxemia unless the toxin was fully neutralized by antitoxin. Second, the. antitoxin mixture was horse serum, the components of which tended to be. allergenic and to sensitize individuals to punctuate title in an the serum. immunity to diphtheria in humans. Diphtheria toxin will cause an inflammatory. reaction when very small amounts are injected intracutaneously. The Schick Test. involves injecting a very small dose of the related research papers, toxin under the punctuate a book title, skin of the forearm. and evaluating the injection site after 48 hours. A positive test (inflammatory.
reaction) indicates susceptibility (nonimmunity). A negative test (no reaction) indicates immunity (antibody neutralizes toxin). but antigenic, equivalent (toxoid) by using formaldehyde. He provided humanity. with one of the related, safest and binding dissertation bournemouth surest vaccines of science, all time-the diphtheria toxoid. strains of C. diphtheriae are lysogenic, (i.e., are infected by a temperate B.
phage), while non lysogenized strains are avirulent. Subsequently, it was shown. that the gene for toxin production is the body electric thesis, located on the DNA of the B phage. on the related papers, mechanism of a action of the diphtheria toxin. They studied the effects. of the toxin in HeLa cell cultures and in cell-free systems, and technology concluded that. the toxin inhibited protein synthesis by blocking the transfer of amino acids.
from tRNA to the growing polypeptide chain on the ribosome. Science Research. They found that this. action of the toxin could be neutralized by prior treatment with diphtheria. toxin has become a classic model of a bacterial exotoxin. local and how to essays systemic pathology. A local lesion develops in the upper respiratory. tract and involves necrotic injury to epithelial cells. As a result of this. injury, blood plasma leaks into the area and a fibrin network forms which is.
interlaced with with rapidly-growing C. diphtheriae cells. This membranous. network covers over the site of the local lesion and is referred to as the. surface epithelial cells at the site of the local lesion. At this site they.
produce the toxin that is absorbed and disseminated through lymph channels and. blood to the susceptible tissues of the body. Degenerative changes in science related research, these. tissues, which include heart, muscle, peripheral nerves, adrenals, kidneys, liver and spleen, result in theme, the systemic pathology of the related papers, disease. of children, and most individuals who survive infancy and childhood have. acquired immunity to diphtheria.
In earlier times, when nonimmune populations. (i.e., Native Americans) were exposed to dissertation the disease, people of all ages were. infected and killed. and subsequent bacterial proliferation. Nothing is known about the adherence. mechanisms of this pathogen. 2.Toxigenesis: bacterial production of the diphtheria toxin. The virulence of. C. diphtheriae cannot be attributed to toxigenicity alone, since a distinct. invasive phase apparently precedes toxigenesis. However, it cannot be ruled out.
that the diphtheria toxin plays a (essential?) role in the colonization process. due to its short-range effects at the colonization site. and mitis. They are listed here by falling order of the severity of the disease. that they produce in humans. All strains produce the identical toxin and research are.
capable of colonizing the throat. The differences in virulence between the three. strains can be explained by their differing abilities to produce the toxin in. rate and quantity, and by their differing growth rates. intermedius strain has a generation time of electric, about 100 minutes; and the mitis. stain has a generation time of about 180 minutes. The faster growing strains. typically produce a larger colony on most growth media. In the throat (in vivo), a faster growth rate may allow the science research, organism to deplete the i sing the body electric thesis, local iron supply.
more rapidly in the invaded tissues, thereby allowing earlier or greater. production of the diphtheria toxin. Also, if the kinetics of toxin production. follow the related research, kinetics of bacterial growth, the faster growing variety would. achieve an effective level of toxin before the slow growing varieties. to produce the diphtheria toxin: (1) low extracellular concentrations of iron.
and (2) the presence of a lysogenic prophage in the bacterial chromosome. Thesis Seo Tutorial. The. gene for research, toxin production occurs on the chromosome of the thesis theme seo tutorial, prophage, but a. bacterial repressor protein controls the expression of this gene. The repressor.
is activated by iron, and it is in this way that iron influences toxin. production. High yields of toxin are synthesized only by lysogenic bacteria. under conditions of iron deficiency. yield of the toxin is the concentration of inorganic iron (Fe++ or Fe+++) present in the culture medium.
Toxin is synthesized in high yield only after the. exogenous supply of iron has become exhausted (This has practical importance for. the industrial production of toxin to research make toxoid. Under the appropriate. conditions of how to do dbq essays, iron starvation, C. diphtheriae will synthesize diphtheria toxin. as 5% of its total protein!). Science Related Research. Presumably, this phenomenon takes place in vivo as.
well. The bacterium may not produce maximal amounts of toxin until the iron. supply in tissues of the upper respiratory tract has become depleted. It is the. regulation of toxin production in the bacterium that is ready for sale, partially controlled by. iron. The tox gene is regulated by a mechanism of negative control wherein a. repressor molecule, product of the DtxR gene, is activated by iron. The active. repressor binds to the tox gene operator and prevents transcription. Related Research. When iron.
is removed from the repressor (under growth conditions of iron limitation), derepression occurs, the repressor is ready, inactivated and transcription of the tox. genes can occur. Iron is referred to papers as a corepressor since it is required for. repression of the toxin gene. are lysogenized by a specific Beta-phage produce diphtheria toxin.
A phage lytic. cycle is not necessary for toxin production or release. Thesis Seo Tutorial. The phage contains the. structural gene for the toxin molecule, since lysogeny by various mutated Beta. phages leads to production of nontoxic but antigenically-related material. (called CRM for cross-reacting material).
CRMs have shorter chain length than. the diphtheria toxin molecule but cross react with diphtheria antitoxins due to. their antigenic similarities to the toxin. The properties of CRMs established. beyond a doubt that the tox genes resided on the phage chromosome rather than. the bacterial chromosome. of toxin production is under bacterial control since the DtxR (regulatory) gene.
is on bacterial chromosome and science related toxin production depends upon bacterial iron. natural history of the bacterium. Of what value should it be to an organism to. synthesize up to 5% of its total protein as a toxin that specifically inhibits. protein synthesis in eukaryotes (and archaebacteria)? Possibly the toxin assists. colonization of the electric, throat (or skin) by science related research killing epithelial cells or neutrophils. There is no evidence to suggest a key role of the toxin in how to do dbq, the life cycle of the. organism. Since mass immunization against diphtheria has been practiced, the.
disease has virtually disappeared, and related C. diphtheriae is no longer a component. of the normal flora of the human throat and pharynx. It may be that the toxin. played a key role in the colonization of the throat in nonimmune individuals and, as a consequence of ready essays for sale, exhaustive immunization, toxigenic strains have become.
single polypeptide chain containing an A (active) domain and a B (binding) domain. Proteolytic nicking of the secreted form of the toxin separates the A. chain from the B chain. susceptible cells and enters by receptor-mediated endocytosis.
Acidification of. the endosome vesicle results in related, unfolding of the protein and insertion of a. segment into the endosomal membrane. Apparently as a result of english technology, activity on the. endosome membrane, the A subunit is research, cleaved and released from the english science essay, B subunit as. it inserts and passes through the membrane. Once in science related research papers, the cytoplasm, the A. fragment regains its conformation and its enzymatic activity.
Fragment A. catalyzes the transfer of ADP-ribose from NAD to seo tutorial the eukaryotic Elongation. Factor 2 which inhibits the science papers, function of the the body electric, latter in protein synthesis. Ultimately, inactivation of all of the host cell EF-2 molecules causes death of. the cell. Attachment of the ADP ribosyyl group occurs at an unusual derivative. of histadine called diphthamide.
Nicotinamide ATox-ADP-Ribose EF-2. trypsin in the presence of thiol. Related Papers. The enzymatic activity of fragment A is masked. in the a book title, intact toxin. Fragment B is science research papers, required to bind the native toxin to its.
cognate receptor and to ready for sale permit the escape of fragment A from the endosome. The C. terminal end of Fragment B contains the peptide region that attaches to the HB- EGF receptor on the sensitive cell membrane, and related research papers the N-terminal end is a. strongly hydrophobic region which will insert into a membrane lipid bilayer. precursor is a protein on the surface of many types of cells. The occurrence and. distribution of the HB-EGF receptor on cells determines the susceptibility of an. animal species, and theme seo tutorial certain cells of an animal species, to the diphtheria toxin.
Normally, the HB-EGF precursor releases a peptide hormone that influences. normal cell growth and differentiation. One hypothesis is that the HB-EGF. receptor itself is the protease that nicks the A fragment and reduces the. disulfide bridge between it and science related the B fragment when the A fragment makes its way. through the endosomal membrane into the cytoplasm. (antitoxin).
Passive immunity in utero is acquired transplacentally and can last. at most 1 or 2 years after birth. In areas where diphtheria is endemic and mass. immunization is not practiced, most young children are highly susceptible to. infection. Probably active immunity can be produced by a mild or inapparent.
infection in infants who retain some maternal immunity, and in do dbq essays, adults infected. with strains of low virulence (inapparent infections). organisms in the throat or nose for weeks or even months. In the past, it was. mainly through such healthy carriers that the disease was spread, and toxigenic.
bacteria were maintained in the population. Before mass immunization of children, carrier rates of C. diphtheriae of 5% or higher were observed. immunization at an early age is science related research papers, universally advocated. Toxoid is given in 2 or 3. doses (1 month apart) for primary immunization at an age of i sing the body electric, 3 - 4 months. A.
booster injection should be given about research papers a year later, and essays for sale it is advisable to. administer several booster injections during childhood. Usually, infants in the. United States are immunized with a trivalent vaccine containing diphtheria. toxoid, pertussis vaccine, and tetanus toxoid (DPT or DTP vaccine).